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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 153 - 160 (8page)
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Phosphatidylinositol phosphates (PtdInsPs) are ubiquitous membrane phospholipids that play diverse roles in cell growth and differentiation. To clarify the regulation mechanism acting on neurofilament light chain (NF-L) self assembly, we examined the effects of various PtdInsPs on this process. We found that PtdInsPs, including PI(4,5)P2, directly bind to the positively charged Arg54 of murine NF-L, and this binding promotes NF-L self assembly in vitro. Mutant NF-L (R53A/R54A) proteins lacking binding affinity to PtdInsPs did not have the same effect, but the mutant NF-L proteins showed greater self assembly than the wild-type in the absence of any PtdInsP. These results collectively suggest that Arg54 plays a pivotal role in NF-L self assembly by binding with PtdInsPs.
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참고문헌 (25)
참고문헌 신청
Al-Chalabi A / 2003 / Neurofilaments and neurological disease / Bioessays 25 : 346 ~ 355
Balla T / 2005 / Inositol-lipid binding motifs: signal integrators through protein-lipid and protein-protein interactions / J Cell Sci 118 : 2093 ~ 2104
Berridge MJ / 1993 / Inositol trisphosphate and calcium signalling / Nature 361 : 315 ~ 325
Carlton JG / 2005 / Coincidence detection in phosphoinositide signaling / Trends Cell Biol 15 : 540 ~ 547
Carter JE / 1996 / Aggregation of neurofilaments in NF-L transfected neuronal cells: regeneration of the filamentous network by a protein kinase C inhibitor / J Neurochem 67
Balla T / 2005 / Inositol-lipid binding motifs: signal integrators through protein-lipid and protein-protein interactions / J Cell Sci 118 : 2093 ~ 2104
Berridge MJ / 1993 / Inositol trisphosphate and calcium signalling / Nature 361 : 315 ~ 325
Carlton JG / 2005 / Coincidence detection in phosphoinositide signaling / Trends Cell Biol 15 : 540 ~ 547
Carter JE / 1996 / Aggregation of neurofilaments in NF-L transfected neuronal cells: regeneration of the filamentous network by a protein kinase C inhibitor / J Neurochem 67
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