지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 231 - 274 (44page)
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Studies of epilepsy have mainly focused on the membrane proteins that control neuronal excitability.
Recently, attention has been shifting to intracellular proteins and their interactions, signaling cascades and feedback regulation as they relate to epilepsy. The mTOR (mammalian target of rapamycin) signal transduction pathway, especially, has been suggested to play an important role in this regard. These pathways are involved in major physiological processes as well as in numerous pathological conditions. Here, involvement of the mTOR pathway in epilepsy will be reviewed by presenting; an overview of the pathway, a brief description of key signaling molecules, a summary of independent reports and possible implications of abnormalities of those molecules in epilepsy, a discussion of the lack of experimental data, and questions raised for the understanding its epileptogenic mechanism.
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참고문헌 (23)
참고문헌 신청
Aeder SE / 2004 / PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways / Oncogene 23 : 9062 ~ 9069
Aguilar V / 2007 / S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase / Cell Metab 5 : 476 ~ 487
Ahn JY / 2005 / PIKE GTPase signaling and function / Int J Biol Sci 1 : 44 ~ 50
Aho TL / 2004 / Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site / FEBS Lett 571 : 43 ~ 49
Albert L / 2009 / Inhibition of mTOR activates the MAPK pathway in glioblastoma multiforme / Cancer Genomics Proteomics 6 : 255 ~ 262
Aguilar V / 2007 / S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase / Cell Metab 5 : 476 ~ 487
Ahn JY / 2005 / PIKE GTPase signaling and function / Int J Biol Sci 1 : 44 ~ 50
Aho TL / 2004 / Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site / FEBS Lett 571 : 43 ~ 49
Albert L / 2009 / Inhibition of mTOR activates the MAPK pathway in glioblastoma multiforme / Cancer Genomics Proteomics 6 : 255 ~ 262
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