지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1 - 8 (8page)
이용수
초록· 키워드
오류제보하기
Airway remodeling is a key characteristic of chronic asthma, particularly in patients with a fixed airflow limitation. The mechanisms underlying airway remodeling are poorly understood, and no therapeutic option is available. The Wnt/β-catenin signaling pathway is involved in various physiological and pathological processes, including fibrosis and smooth muscle hypertrophy. In this study, we investigated the roles of Wnt/β-catenin signaling in airway remodeling in patients with asthma. Wnt7a mRNA expression was prominent in induced sputum from patients with asthma compared with that from healthy controls. Next, we induced a chronic asthma mouse model with airway remodeling features, including subepithelial fibrosis and airway smooth muscle hyperplasia. Higher expression of Wnt family proteins and β-catenin was detected in the lung tissue of mice with chronic asthma compared to control mice. Blocking β-catenin expression with a specific siRNA attenuated airway inflammation and airway remodeling. Decreased subepithelial fibrosis and collagen accumulation in the β-catenin siRNA-treated mice was accompanied by reduced expression of transforming growth factor-β. We further showed that suppressing β-catenin in the chronic asthma model inhibited smooth muscle hyperplasia by downregulating the tenascin C/platelet-derived growth factor receptor pathway. Taken together, these findings demonstrate that the Wnt/β-catenin signaling pathway is highly expressed and regulates the development of airway remodeling in chronic asthma.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Al-Muhsen S / 2011 / Remodeling in asthma / J Allergy Clin Immunol 128 : 451 ~ 462
Berair R / 2014 / Asthma therapy and its effect on airway remodelling / Drugs 74 : 1345 ~ 1369
Chilosi M / 2003 / Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis / Am J Pathol 162 : 1495 ~ 1502
Choy DF / 2011 / Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways / J Immunol 186 : 1861 ~ 1869
Clevers H / 2012 / Wnt/beta-catenin signaling and disease / Cell 149 : 1192 ~ 1205
Berair R / 2014 / Asthma therapy and its effect on airway remodelling / Drugs 74 : 1345 ~ 1369
Chilosi M / 2003 / Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis / Am J Pathol 162 : 1495 ~ 1502
Choy DF / 2011 / Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways / J Immunol 186 : 1861 ~ 1869
Clevers H / 2012 / Wnt/beta-catenin signaling and disease / Cell 149 : 1192 ~ 1205
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Wnt5a attenuates the pathogenic effects of the Wnt/β-catenin pathway in human retinal pigment epithelial cells via down-regulating β-catenin and Snail
BMB Reports
2015 .01
-
Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex
Experimental and Molecular Medicine
2020 .02
-
Mechanosensitive β-catenin signaling regulates lymphatic vascular development
BMB Reports
2016 .01
-
Cloning, Purification and NMR Studies on β-catenin C-terminal Domain
Journal of the Korean Magnetic Resonance Society
2017 .01
-
S-adenosylmethionine reduces airway inflammation and fibrosis in a murine model of chronic severe asthma via suppression of oxidative stress
Experimental and Molecular Medicine
2016 .01
-
Simultaneous destabilization of β-catenin and Ras via targeting of the axin-RGS domain as a potential therapeutic strategy for colorectal cancer
BMB Reports
2016 .01
-
Wnt/β-catenin signaling activator restores hair regeneration suppressed by diabetes mellitus
BMB Reports
2022 .11
-
Curcumin polymeric micelles suppress the Wnt/Beta-Catenin signaling pathway target colon cancer
한국고분자학회 학술대회 연구논문 초록집
2016 .04
-
Hypermethylation of Frizzled1 is associated with Wnt/β-catenin signaling inactivation in mesenchymal stem cells of patients with steroid-associated osteonecrosis
Experimental and Molecular Medicine
2019 .01
-
Curcumin polymeric micelles as inhibitor of the Wnt/beta-catenin signaling pathway target colon cancer
한국고분자학회 학술대회 연구논문 초록집
2017 .04
-
Euodia sutchuenensis Dode extract stimulates osteoblast differentiation via Wnt/β-catenin pathway activation
Experimental and Molecular Medicine
2015 .01
-
Merlin, a regulator of Hippo signaling, regulates Wnt/β-catenin signaling
BMB Reports
2016 .01
-
Inhibition of Cyclooxygenase-2 Alters Wnt/b-Catenin Signaling in the Regenerating Tail of Lizard Hemidactylus flaviviridis
조직공학과 재생의학
2017 .01
-
Distinctive Roles of Wnt Signaling in Chondrogenic Differentiation of BMSCs under Coupling of Pressure and Platelet-Rich Fibrin
조직공학과 재생의학
2022 .08
-
LGK974 suppresses lipopolysaccharide-induced endotoxemia in mice by modulating the crosstalk between the Wnt/β-catenin and NF-κB pathways
Experimental and Molecular Medicine
2021 .03
-
Interacting network of Hippo, Wnt/β-catenin and Notch signaling represses liver tumor formation
BMB Reports
2017 .01
-
Enhancing Osteogenic Effect of Gallic Acid-g-chitosan Through Wnt/beta-catenin Signaling Pathway
한국생물공학회 학술대회
2021 .04
-
Emodin prevents intima thickness via Wnt4/Dvl-1/β-catenin signaling pathway mediated by miR-126 in balloon-injured carotid artery rats
Experimental and Molecular Medicine
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0