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논문 기본 정보
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- 학술저널
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제16권 제7호
- 발행연도
- 2006.1
- 수록면
- 1,017 - 1,025 (9page)
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초록· 키워드
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Hantaviruses possess three RNA segments ofnegative sense. Co-infection of closely related hantavirusesmay result in generation of a progeny virus with genomicpolyploidy, containing a partial or complete set of genomethe formation of viral genomic polyploidy, cultured Vero-E6cells were co-infected with two closely related hantaviruses,Hantaan and Maaji, and the progeny viruses examined. Thegenotype of plaque-purified viruses was analyzed by a virus-specific RT-PCR. Seventy percent (67/96) of the progeny viruswas categorized as Hantaan and 3.3% (2/96) was classified asMaji, whereas 20% (21/96) was considered polyploidy asthey contained both types of the S RNA segment. Most of theeither one of the parental viruses or a reasortant after severalrounds of plaque purification. No recombination betwen theheterologous pair of S RNA was observed for those polyploidviruses during three consecutive plaque-to-plaque pasages.These data suggest that the viral polyploidy formation constitutesa primary mechanism underlying the generation of a newlyemerged hantavirus.
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참고문헌 (25)
참고문헌 신청
Antic, D / 1992 / Comparison of the deduced gene products of the L, M and S genome segments of hantaviruses / Virus Res. 24 : 35 ~ 46
Beaty, B. J / 1985 / Evolution of bunyaviruses by genome reassortment in dually infected mosquitoes (Aedes triseriatus) / Science 230 : 548 ~ 550
Beaty, B. J / 1996 / Factors in the Emergence of Arbovirus Diseases, Emerging Diseases / Elsevier, Paris : 23 ~ 35
Bishop, D. H / 1988 / Molecular and biochemical studies of the evolution, infection and transmission of insect bunyaviruses / Philos. Trans. R. Soc. Lond. B Biol. Sci. 321 :
Bishop, D. H. / 1985 / The genetic basis for describing viruses as species / Intervirology 24 : 79 ~ 93
Beaty, B. J / 1985 / Evolution of bunyaviruses by genome reassortment in dually infected mosquitoes (Aedes triseriatus) / Science 230 : 548 ~ 550
Beaty, B. J / 1996 / Factors in the Emergence of Arbovirus Diseases, Emerging Diseases / Elsevier, Paris : 23 ~ 35
Bishop, D. H / 1988 / Molecular and biochemical studies of the evolution, infection and transmission of insect bunyaviruses / Philos. Trans. R. Soc. Lond. B Biol. Sci. 321 :
Bishop, D. H. / 1985 / The genetic basis for describing viruses as species / Intervirology 24 : 79 ~ 93
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