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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제20권 제1호
- 발행연도
- 2010.1
- 수록면
- 82 - 87 (6page)
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초록· 키워드
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Biotransformation is often used to improve chemical activity.
We evaluated the antimicrobial activity of rhapontigenin,converted from rhapontin after treatment with Pectinex.
Rhapontigenin showed 4–16 times higher antimicrobial activity than rhapontin. The activity was higher against Gram-positive strains than Gram-negative strains. Minimum inhibitory concentrations (MICs) of rhapontigenin, retinol,and five antibiotics were determined by the microbroth dilution method for antibiotic-sensitive and -resistant Propionibacterium acnes. We also investigated the in vitro antibacterial activity of rhapontigenin in combination with antibiotic against antibiotic-resistant P. acnes. The antibiotic combination effect against resistant P. acnes was studied by the checkerboard method. The combination formulations (rhapontigenin and clindamycin, retinol and clindamycin) showed synergistic effects on the inhibition of the growth of clindamycin-resistant P. acnes. It is predictable that the combination of antibiotics with rhapontigenin is helpful to treat acne caused by antibiotic-resistant P. acnes. The antibacterial activity of rhapontigenin was enhanced by biotransformation.
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참고문헌 (21)
참고문헌 신청
Belofsky, G / 2006 / Metabolites of the “Smoke tree”, Dalea spinosa, potentiate antibiotic activity against multidrug-resistant Staphylococcus aureus / J. Nat. Prod 69 : 26
Chabot, S / 1992 / Hyphal growth in vitro of the VA mycorrhizal fungus, Gigaspora margarita Becker & Hall, by the activity of structurally specific flavonoids compounds u
Chivot, M / 2005 / Retinoid therapy for acne / Am. J. Clin. Dermatol 6 : 13 ~ 19
Coates, P / 2002 / Prevalence of antibiotic-resistant propionibacteria on the skin of acne patients: 10-Year surveillance data and snapshot distribution study / Br. J. Dermat
Davidson, P. M / 1981 / Antimicrobial activity of non-halogenated phenolic compounds / J. Food Prot 44 : 623 ~ 632
Chabot, S / 1992 / Hyphal growth in vitro of the VA mycorrhizal fungus, Gigaspora margarita Becker & Hall, by the activity of structurally specific flavonoids compounds u
Chivot, M / 2005 / Retinoid therapy for acne / Am. J. Clin. Dermatol 6 : 13 ~ 19
Coates, P / 2002 / Prevalence of antibiotic-resistant propionibacteria on the skin of acne patients: 10-Year surveillance data and snapshot distribution study / Br. J. Dermat
Davidson, P. M / 1981 / Antimicrobial activity of non-halogenated phenolic compounds / J. Food Prot 44 : 623 ~ 632
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