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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제2호
- 발행연도
- 2008.1
- 수록면
- 355 - 364 (10page)
이용수
초록· 키워드
오류제보하기
Mushrooms are regarded as one of the well-known foods and biopharmaceutical materials with a great deal of interest. β-Glucan is the major component of mushrooms that displays various biological activities such as antidiabetic, anticancer, and antihyperlipidemic effects. In this study, we explored the molecular mechanism of its immunostimulatory potency in immune responses of macrophages, using exopolysaccharides prepared from liquid culture of Lentinus edodes. We found that fraction II (F-II), with large molecular weight protein polysaccharides, is able to strongly upregulate the phenotypic functions of macrophages such as phagocytic uptake, ROS/NO production, cytokine expression, and morphological changes. F-II triggered the nuclear translocation of NF-κB and activated its upstream signaling cascades such as PI3K/Akt and MAPK pathways, as assessed by their phosphorylation levels. The functionblocking antibodies to dectin-1 and TLR-2, but not CR3, markedly suppressed F-II-mediated NO production.
Therefore, our data suggest that mushroom-derived β- glucan may exert its immunostimulating potency via activation of multiple signaling pathways.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Akamatsu, S. / 2004 / Hepatoprotective effect of extracts from Lentinus edodes mycelia on dimethylnitrosamine-induced liver injury. Biol. Pharm / Bull 27 : 1957 ~ 1960
Allavena, P. / 2004 / From pattern recognition receptor to regulator of homeostasis: The double-faced macrophage mannose receptor. Crit. Rev / Immunol 24 : 179 ~ 192
Borchers, A. T. / 1999 / Mushrooms, tumors, and immunity. Proc. Soc. Exp. Biol / Med 221 : 281 ~ 293
Brown, G. D. / 2002 / Dectin-1 is a major beta-glucan receptor on macrophages. J. Exp / Med 196 : 407 ~ 412
Brown, G. D. / 2003 / Dectin-1 mediates the biological effects of beta-glucans. J. Exp / Med 197 : 1119 ~ 1124
Allavena, P. / 2004 / From pattern recognition receptor to regulator of homeostasis: The double-faced macrophage mannose receptor. Crit. Rev / Immunol 24 : 179 ~ 192
Borchers, A. T. / 1999 / Mushrooms, tumors, and immunity. Proc. Soc. Exp. Biol / Med 221 : 281 ~ 293
Brown, G. D. / 2002 / Dectin-1 is a major beta-glucan receptor on macrophages. J. Exp / Med 196 : 407 ~ 412
Brown, G. D. / 2003 / Dectin-1 mediates the biological effects of beta-glucans. J. Exp / Med 197 : 1119 ~ 1124
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