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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제20권 제3호
- 발행연도
- 2010.1
- 수록면
- 643 - 649 (7page)
이용수
초록· 키워드
오류제보하기
Evaluation of the primary etiologic agents that cause aseptic meningitis outbreaks may provide valuable information regarding the prevention and management of aseptic meningitis. In Korea, an outbreak of aseptic meningitis caused by echovirus type 30 (E30) occurred from May to October in 2008. In order to determine the etiologic agent,CSF and/or stool specimens from 140 children hospitalized for aseptic meningitis at Soonchunhyang University Cheonan Hospital between June and October of 2008were tested for virus isolation and identification. E30accounted for 61.7% (37 cases) and echovirus 6 accounted for 21.7% (13 cases) of all the human enteroviruses (HEVs) isolates (60 cases in total). For the molecular characterization of the isolates, the VP1 gene sequence of 18 Korean E30 isolates was compared pairwise using the MegAlign with 34 reference strains from the GenBank database. The pairwise comparison of the nucleotide sequences of the VP1 genes demonstrated that the sequences of the Korean strains differed from those of lineage groups A, B, C, D, E, F, and G. Reconstruction of the phylogenetic tree based on the complete VP1 nucleotide sequences resulted in a monophyletic tree, with eight clustered lineage groups. All Korean isolates were segregated from other lineage groups, thus suggesting that the Korean strains were a distinct lineage of E30, and a probable cause of this outbreak. This manuscript is the first report,to the best of our knowledge, of the molecular characteristics of E30 strains associated with an aseptic meningitis outbreak in Korea, and their respective phylogenetic relationships.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Akiyoshi, K / 2007 / An outbreak of aseptic meningitis in a nursery school caused by echovirus type 30 in Kobe / Japan. Jpn. J. Infect. Dis 60 : 66 ~ 68
Bailly, J. L / 2002 / Genetic diversity of echovirus 30 during a meningitis outbreak, demonstrated by direct molecular typing from cerebrospinal fluid / J. Med. Virol 68 : 55
Casas, I / 2001 / Molecular characterization of human enteroviruses in clinical samples: Comparison between VP2, VP1, and RNA polymerase regions using RT nested PCR assays an
Irani, D. N / 2008 / Aseptic meningitis and viral myelitis / Neurol. Clin 26 : 635 ~ 655
Kim, H. K / 1993 / Echovirus type 9 infection in an epidemic of aseptic meningitis in 1993 / Korean J. Clin. Pathol 14 : 185 ~ 192
Bailly, J. L / 2002 / Genetic diversity of echovirus 30 during a meningitis outbreak, demonstrated by direct molecular typing from cerebrospinal fluid / J. Med. Virol 68 : 55
Casas, I / 2001 / Molecular characterization of human enteroviruses in clinical samples: Comparison between VP2, VP1, and RNA polymerase regions using RT nested PCR assays an
Irani, D. N / 2008 / Aseptic meningitis and viral myelitis / Neurol. Clin 26 : 635 ~ 655
Kim, H. K / 1993 / Echovirus type 9 infection in an epidemic of aseptic meningitis in 1993 / Korean J. Clin. Pathol 14 : 185 ~ 192
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