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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
한국미생물생명공학회 한국미생물·생명공학회지 한국미생물·생명공학회지 제42권 제4호
발행연도
2014.1
수록면
361 - 366 (6page)

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초록· 키워드

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In this study, Glycyrrhiza uralensis and Glycyrrhiza glabra extracts, with their countries of origin as Korea (Jecheon), Uzbekistan and China, were prepared under various extraction conditions. There were 8 extraction conditions which the licorice were subjected to, and all conditions had different extraction solvents, temperatures and times. Antimicrobial activity on skin flora was evaluated comparatively by a disc diffusion assay, broth macrodilution assay, and kill time curve assay. Based on the antimicrobial activity of their extract confirmed by disc diffusion assay, we established optimal extraction conditions. The Korean licorice extract (85% ethanol, 40℃, 12 h) showed the best activity amongst the samples examined. In particular, its antimicrobial activity against Propionibacterium acnes was the highest. Minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) of the licorice extracts revealed that the Korean licorice (156 μg/ml and 1,250 μg/ml) had better antimicrobial activity than that of the Uzbekistani licorice (625 μg/ml and 2,500 μg/ml) and the Chinese licorice (625 μg/ml and 5,000 μg/ml). Taken together, it was shown that Korean licorice extracted in group F (85% ethanol, 40℃, 12 h) had the highest antimicrobial activity amongst the licorices from the other countries of origin. These results also suggest that the optimal extraction conditions are 85% ethanol, 40℃, 12 h, and that licorice has a potential application as a natural preservative in cosmetics products, thereby replacing synthetic preservatives.

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