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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제1호
- 발행연도
- 2008.1
- 수록면
- 80 - 87 (8page)
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초록· 키워드
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The 3T3-L1 cell line is a well-established and commonly
used in vitro model to assess adipocyte differentiation.
Over the course of several days, confluent 3T3-L1 cells
can be converted to adipocytes in the presence of an
adipogenic cocktail. In this study, the effects of chitosan
oligosaccharides (CO) on adipocyte differentiation of 3T3-
L1 cells were studied. The CO significantly decreased
lipid accumulation, a marker of adipogenesis, in a dosedependent
manner. The low molecular mass CO (1-
3 kDa) were the most effective at inhibiting adipocyte
differentiation. Moreover, mRNA expression levels of
both CCAAT/enhancer-binding protein (C/EBP) α and
peroxisome proliferator-activated receptor (PPAR) γ, the key
adipogenic transcription factors, were markedly decreased
by CO treatments. CO also significantly downregulated
adipogenic marker proteins such as leptin, adiponectin,
and resistin. Our results suggest a role for CO as antiobesity
agents by inhibiting adipocyte differentiation
mediated through the downregulated expression of
adipogenic transcription factors and other specific genes.
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참고문헌 (24)
참고문헌 신청
Bradford, M. M / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal / Biochem 72
Coe, N. R. / 1999 / Targeted disruption of the adipocyte lipid-binding protein (aP2 protein) gene impairs fat cell lipolysis and increases cellular fatty acid levels / Lipid
Cornelius, P. / 1994 / Regulation of adipocyte development. Annu. Rev / Nutr 14 : 99 ~ 129
Darlington, G. J. / 1998 / The role of C/EBP genes in adipocyte differentiation. J. Biol / Chem 273 : 30057 ~ 30060
Fong, J. C. / 1999 / Synergistic effect of arachidonic acid and cyclic AMP on glucose transport in 3T3-L1 adipocytes. Cell / Signal 11 : 53 ~ 58
Coe, N. R. / 1999 / Targeted disruption of the adipocyte lipid-binding protein (aP2 protein) gene impairs fat cell lipolysis and increases cellular fatty acid levels / Lipid
Cornelius, P. / 1994 / Regulation of adipocyte development. Annu. Rev / Nutr 14 : 99 ~ 129
Darlington, G. J. / 1998 / The role of C/EBP genes in adipocyte differentiation. J. Biol / Chem 273 : 30057 ~ 30060
Fong, J. C. / 1999 / Synergistic effect of arachidonic acid and cyclic AMP on glucose transport in 3T3-L1 adipocytes. Cell / Signal 11 : 53 ~ 58
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