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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제22권 제10호
- 발행연도
- 2012.1
- 수록면
- 1,381 - 1,387 (7page)
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초록· 키워드
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We applied enzymatic hydrolysis and tangential flow filtration (TFF) to purify a novel anticancer peptide from Mytilus coruscus (M. coruscus) and investigated its anticancer properties. To prepare the peptide, eight proteases were employed for enzymatic hydrolysis. Pepsin hydrolysates,which showed clearly superior cytotoxic activity on prostate cancer cells, were further purified using a flow filtration system using a TFF and consecutive chromatographic methods. Finally, a novel anticancer peptide was obtained,and the sequence was identified as Ala-Phe-Asn-Ile-His-Asn-Arg-Asn-Leu-Leu. The peptide from M. coruscus effectively induced cell death on prostate, breast and lung cancer cells but not on normal liver cells. This is the first report of an anticancer peptide derived from the hydrolysates of M. coruscus.
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참고문헌 (23)
참고문헌 신청
Baker, M. A. / 1993 / Anticancer efficacy of magainin2 and analogue peptides / Cancer Res 53 : 3052 ~ 3057
Cesaretti, M. / 2004 / Isolation and characterization of a heparin with high anticoagulant activity from the clam Tapes phylippinarum: Evidence for the presence of a high con
Chen, H. M. / 1995 / Structural analysis of antioxidative peptides from soybean beta-conglycinin / J. Agric. Food Chem 43 : 574 ~ 578
Fernandez, R. C. / 1996 / Susceptibilities of Bordetella pertussis strains to antimicrobial peptides / Antimicrob. Agents Chemother 40 : 1041 ~ 1043
Je, J. Y. / 2005 / Anticancer activity of a peptide isolated from Alaska pollack (Theragra chalcogramma) frame protein hydrolysate / Food Res. Int 38 : 45 ~ 50
Cesaretti, M. / 2004 / Isolation and characterization of a heparin with high anticoagulant activity from the clam Tapes phylippinarum: Evidence for the presence of a high con
Chen, H. M. / 1995 / Structural analysis of antioxidative peptides from soybean beta-conglycinin / J. Agric. Food Chem 43 : 574 ~ 578
Fernandez, R. C. / 1996 / Susceptibilities of Bordetella pertussis strains to antimicrobial peptides / Antimicrob. Agents Chemother 40 : 1041 ~ 1043
Je, J. Y. / 2005 / Anticancer activity of a peptide isolated from Alaska pollack (Theragra chalcogramma) frame protein hydrolysate / Food Res. Int 38 : 45 ~ 50
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