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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제9호
- 발행연도
- 2015.1
- 수록면
- 1,559 - 1,567 (9page)
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초록· 키워드
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The combination of trimethoprim (TMP) and sulfamethoxazole (SMX) has been shown to be active against Mycobacterium tuberculosis (Mtb) in clinical tuberculosis (TB) treatment. However, the mechanism of action of TMP-SMX against Mtb is still unknown. To unravel this, we have studied the effect of TMP and SMX by deleting the folP2 gene in Mycobacterium smegmatis (Msm), and overexpressing the Mtb and Msm folP1/2 genes in Msm. Knocking out of the folP2 gene in Msm reduced the minimum inhibitory concentration of SMX 8-fold compared with wild type. Overexpression of the folP1 genes from Mtb and Msm increased the MICs by 4- and 2-fold in Msm for SMX and TMP, respectively. We show a strong correlation between the expression of folP1 and folP2 genes and TMP-SMX resistance in mycobacteria. This suggests that a combination of FolP2 inhibitor and SMX could be used for TB treatment with a better outcome.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Balan P / 2011 / Ovine serum immunoglobulin has immunomodulatory effects in growing rats gavaged with Salmonella enteritidis / J. Nutr 141 : 950 ~ 956
Castillo M / 2006 / The response of gastrointestinal microbiota to avilamycin, butyrate, and plant extracts in early-weaned pigs / J. Anim. Sci 84 : 2725 ~ 2734
Castillo M / 2007 / Changes in caecal microbiota and mucosal morphology of weaned pigs / Vet. Microbiol 124 : 239 ~ 247
De Preter V / 2010 / The prebiotic, oligofructose-enriched inulin modulates the faecal metabolite profile: an in vitro analysis / Mol. Nutr. Food Res 54 : 1791 ~ 1801
Everard A / 2013 / Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity / Proc. Natl. Acad. Sci. USA 110 : 9066 ~ 9071
Castillo M / 2006 / The response of gastrointestinal microbiota to avilamycin, butyrate, and plant extracts in early-weaned pigs / J. Anim. Sci 84 : 2725 ~ 2734
Castillo M / 2007 / Changes in caecal microbiota and mucosal morphology of weaned pigs / Vet. Microbiol 124 : 239 ~ 247
De Preter V / 2010 / The prebiotic, oligofructose-enriched inulin modulates the faecal metabolite profile: an in vitro analysis / Mol. Nutr. Food Res 54 : 1791 ~ 1801
Everard A / 2013 / Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity / Proc. Natl. Acad. Sci. USA 110 : 9066 ~ 9071
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