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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 277 - 287 (11page)
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초록· 키워드
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Current reports suggest that obesity is a serious global health issue. Emerging evidence has predicted strong links between obesity and the human gut microbiota. However, only a few such studies have been conducted in Asia, and the gut microbiota of lean and obese adult Asians remains largely unexplored. Here, we investigated the potential relationship between gut microbiota, body massindex (BMI), and metabolic parameters in adults from Thailand, where obesity is increasing rapidly. Fecal and blood samples were collected from 42 volunteers who were allocated into lean, overweight, and obese groups. The fecal microbiota was examined by quantitative PCR analysis. Bacteroidetes, Firmicutes, and Staphylococcus spp. and methanogens were most abundant in lean volunteers. Overweight volunteers majorly harbored Christensenella minuta and Akkermansia muciniphila, γ-Proteobacteria, and bacteria belonging to the genus Ruminococcus. Methanogens and bacteria belonging to the phylum Bacteroidetes were negatively correlated with adiposity markers (BMI and waist circumference), but positive correlated with high-density lipoprotein, suggesting that they can be used as leanness markers. While some of our results agree with those of previous reports, results regarding the contributions of specific taxa to obesity were inconsistent. This is the first study to report the adult gut microbiota in Southeast Asian populations using molecular techniques and biochemical markers and provides a foundation for future studies in this field.
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참고문헌 (53)
참고문헌 신청
Barlow GM / 2015 / Role of the gut microbiome in obesity and diabetes Mellitus / Nutr. Clin. Pract. 30:787~797
Patterson E / 2016 / Gut microbiota, obesity and diabetes / Postgrad. Med. J. 92:286~300
World Health Organization / 2000 / Obesity: preventing and managing the global epidemic / World Health Organ. Tech. Rep. Ser. 894:1~253
Cani PD / 2007 / Metabolic endotoxemia initiates obesity and insulin resistance / Diabetes 56:1761~1772
World Health Organization / 2014 / Global Status Report on noncommunicable diseases
Patterson E / 2016 / Gut microbiota, obesity and diabetes / Postgrad. Med. J. 92:286~300
World Health Organization / 2000 / Obesity: preventing and managing the global epidemic / World Health Organ. Tech. Rep. Ser. 894:1~253
Cani PD / 2007 / Metabolic endotoxemia initiates obesity and insulin resistance / Diabetes 56:1761~1772
World Health Organization / 2014 / Global Status Report on noncommunicable diseases
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