지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 371 - 379 (9page)
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초록· 키워드
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This study was designed to explore new nutraceutical and cosmetic resources possessing biological activities from the plant kingdom. To fulfill this purpose, we analyzed the anti-oxidative, anti-melanogenic,and anti-inflammatory activities of Zanthoxylum schinifolium extract (ZSE) and its solvent fractions using in vitro assays and cell culture model systems. Three kinds of ZSE treated with methanol, ethanol, and water exhibited potent anti-oxidative activities through DPPH radical scavenging capacity, and inhibited in vitro DOPA oxidation. Furthermore, Z. schinifolium methanol extract (ZSME) inhibited the α-melanocyte stimulating hormone, which induces melanin contents in B16F10 cells. Its anti-melanogenic activity originates from the inhibition of tyrosinase enzyme activity and melanogenesis related protein expression. Moreover, lipopolysaccharide induced nitric oxide production in the RAW 264.7 cell line was also ameliorated by ZSME treatment in a dose dependent manner. Among the four solvent fractions of ZSME treated with dichloromethane, ethyl acetate, nbutanol,and water, three fractions, except water, showed significant anti-melanogenic and anti-inflammatory activities. Taken together, these results provide important new insights into Z. schinifolium, indicating that it possesses numerous biological activities such as anti-oxidative, anti-melanogenic, and anti-inflammatory activities.
Therefore, it may well serve as a promising material in the field of nutraceuticals and cosmetics.
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참고문헌 (26)
참고문헌 신청
[학술지(정기간행물)]
Agar, N / 2005 / Melanogenesis: a photoprotective response to DNA damage? / Mutat. Res 571 : 121 ~ 132
Cabanes, J / 1994 / Kojic acid, a cosmetic skin whitening agent, is a slowbinding inhibitor of catecholase activity of tyrosinase / J. Pharm. Pharmacol 46 : 982 ~ 985
Callender, V. D / 2011 / Postinflammatory hyperpigmentation: etiologic and therapeutic considerations / Am. J. Clin. Dermatol 12 : 87 ~ 99
Chan, T. T / 2011 / Inhibitory effects of Sargassum polycystum on tyrosinase activity and melanin formation in B16F10 murine melanoma cells / J. Ethnopharmacol 137 : 1183 ~ 1
Agar, N / 2005 / Melanogenesis: a photoprotective response to DNA damage? / Mutat. Res 571 : 121 ~ 132
Cabanes, J / 1994 / Kojic acid, a cosmetic skin whitening agent, is a slowbinding inhibitor of catecholase activity of tyrosinase / J. Pharm. Pharmacol 46 : 982 ~ 985
Callender, V. D / 2011 / Postinflammatory hyperpigmentation: etiologic and therapeutic considerations / Am. J. Clin. Dermatol 12 : 87 ~ 99
Chan, T. T / 2011 / Inhibitory effects of Sargassum polycystum on tyrosinase activity and melanin formation in B16F10 murine melanoma cells / J. Ethnopharmacol 137 : 1183 ~ 1
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