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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제21권 제6호
- 발행연도
- 2011.1
- 수록면
- 599 - 603 (5page)
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초록· 키워드
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A new geldanamycin (GDM) derivative was discovered and isolated from the fermentation broth of Streptomyces hygroscopicus 17997. Its chemical structure was elucidated as thiazinogeldanamycin by LC-MS, sulfur analysis, and NMR. The addition of cysteine to the fermentation medium significantly stimulated the production level of thiazinogeldanamycin, suggesting cysteine as a precursor of thiazinogeldanamycin production. Although showing a decreased cytotoxicity against HepG2 cancer cells,thiazinogeldanamycin exhibited an improved water solubility and photostability. Thiazinogeldanamycin may represent the first natural GDM derivative characterized so far that uses GDM as its precursor. Its appearance also clearly indicates that an appropriate end-point of fermentation is of critical importance for the maximal production of GDM by Streptomyces hygroscopicus 17997.
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참고문헌 (17)
참고문헌 신청
Charifson, P. S / 1999 / Consensus scoring: A method for obtaining improved hit rates from docking databases of three-dimensional structures into proteins / J. Med. Chem 42 :
Cricchio, R. / 1980 / Thiazorifamycins. III. Biosynthesis of rifamycins P, Q and verde, novel metabolites from a mutant of Nocardia mediterranea / J. Antibiot. (Tokyo) 33 : 8
DeBoer, C / 1970 / Geldanamycin, a new antibiotic / J. Antibiot. (Tokyo) 23 : 442 ~ 447
Ge, J. / 2006 / Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90 / J
Hong, Y. S / 2004 / Inactivation of the carbamoyltransferase gene refines post-polyketide synthase modification steps in the biosynthesis of the antitumor agent geldanamycin
Cricchio, R. / 1980 / Thiazorifamycins. III. Biosynthesis of rifamycins P, Q and verde, novel metabolites from a mutant of Nocardia mediterranea / J. Antibiot. (Tokyo) 33 : 8
DeBoer, C / 1970 / Geldanamycin, a new antibiotic / J. Antibiot. (Tokyo) 23 : 442 ~ 447
Ge, J. / 2006 / Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90 / J
Hong, Y. S / 2004 / Inactivation of the carbamoyltransferase gene refines post-polyketide synthase modification steps in the biosynthesis of the antitumor agent geldanamycin
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