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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제10호
- 발행연도
- 2018.1
- 수록면
- 1,716 - 1,722 (7page)
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초록· 키워드
오류제보하기
Immunosuppressive drugs are used to make the body less likely to reject transplanted organs or to treat autoimmune diseases. In this study, five immunosuppressive drugs including two glucocorticoids (dexamethasone and prednisolone), one calcineurin inhibitor (cyclosporin A), one non-steroid anti-inflammatory drug (aspirin), and one antimetabolite (methotrexate) were tested for their effects on viral proliferation using feline foamy virus (FFV). The five drugs had different cytotoxic effects on the Crandell-Ress feline kidney (CRFK) cells, the natural host cell of FFV. Dexamethasone-pretreated CRFK cells were susceptible to FFV infection, but pretreatment with prednisolone, cyclosporin A, aspirin, and methotrexate showed obvious inhibitory effects on FFV proliferation, by reducing viral production to 29.8-83.8% of that of an untreated control. These results were supported by western blot, which detected viral Gag structural protein in the infected cell lysate. As our results showed a correlation between immunosuppressive drugs and susceptibility to viral infections, it is proposed that immunecompromised individuals who are using immune-suppressive drugs may be especially vulnerable to viral infection originated from pets.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Long PL / 1970 / Extended schizogony of Eimeria mivati in betamethasone-treated chickens / Parasitology 60:147~155
Corrier DE / 1990 / Evaluation of cell-mediated, cutaneous basophil hypersensitivity in young chickens by an interdigital skin test / Poult. Sci 69:403~408
Isobe T / 1992 / Effects of corticosteroids on lymphocyte subpopulations and lymphokine secretion in chickens / Avian Dis :590~596
Borel JF / 1977 / Effects of the new anti-lymphocytic peptide cyclosporin A in animals / Immunology 32:1017~1025
Algra AM / 2012 / Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials / Lancet Oncol 13:518~527
Corrier DE / 1990 / Evaluation of cell-mediated, cutaneous basophil hypersensitivity in young chickens by an interdigital skin test / Poult. Sci 69:403~408
Isobe T / 1992 / Effects of corticosteroids on lymphocyte subpopulations and lymphokine secretion in chickens / Avian Dis :590~596
Borel JF / 1977 / Effects of the new anti-lymphocytic peptide cyclosporin A in animals / Immunology 32:1017~1025
Algra AM / 2012 / Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials / Lancet Oncol 13:518~527
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