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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제17권 제12호
- 발행연도
- 2007.1
- 수록면
- 2,042 - 2,045 (4page)
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초록· 키워드
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The effect of chitosan oligosaccharide (COS, 1 kDa<MW<3 kDa) on proinflamatory cytokines-induced nitricoxide (NO) production and invasivenes of human colorectaladenocarcinoma HT-29 cells was investigated. COS (0.1-5mg/ml) suppressed the NO production induced by proinflammatorycytokines (100 U/ml IFN-γ, 10 ng/ml IL-1α, and 25 ng/mlTNF-α) in HT-29 cells. Inducible nitric oxide synthase(iNOS) expresion induced by these cytokines was inhibitedby COS. COS pretreatment inhibited the invasivenes ofcytokines-treated HT-29 cells through Matrigel-coated membranein a dose-dependent manner. COS also inhibited cytokines-induced matrix metalloproteinase (MMP)-2 activity. This studyshows that proinflammatory cytokines induce NO production,iNOS expresion, and invasiveness of human colorectalcytokines-mediated NO production, iNOS expresion, andinvasiveness of HT-29 cels. These results provide suficientinformation for the further development of COS as anantitumor metastatic agent for the treatment of colon cancer.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
/ 1988 / Functional propertiesof soy protein hydrolysates from a continuous ultrafiltrationreactor : 26 ~ 31
Ambs, S / 1998 / Frequent nitric oxidesynthase-2 expression in human colon adenomas: Implicationfor tumor angiogenesis and colon cancer progression 58 : 334 ~ 341
Brinckerhoff, C. E / 2002 / Matrixmetalloproteinases: A tail of a frog that became a prince 3 : 207 ~ 214
Brown, P. D / 1998 / Matrix metalloproteinases ingastrointestinal cancer 43 : 161 ~ 163
Folkman, J / 1997 / Angiogenesis and angiogenesis inhibition:An overview 79 : 1 ~ 8
Ambs, S / 1998 / Frequent nitric oxidesynthase-2 expression in human colon adenomas: Implicationfor tumor angiogenesis and colon cancer progression 58 : 334 ~ 341
Brinckerhoff, C. E / 2002 / Matrixmetalloproteinases: A tail of a frog that became a prince 3 : 207 ~ 214
Brown, P. D / 1998 / Matrix metalloproteinases ingastrointestinal cancer 43 : 161 ~ 163
Folkman, J / 1997 / Angiogenesis and angiogenesis inhibition:An overview 79 : 1 ~ 8
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