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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제17권 제12호
- 발행연도
- 2007.1
- 수록면
- 2,033 - 2,041 (9page)
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For many years, it has been demonstrated thattheir potential as therapeutic agents for the treatment ofneurodegenerative diseases. We generated adenoviral vectorsencoding brain-derived neutotrophin factor (BDNF) andneurotrophin-3 (NT3) and tested either separately or togetherfor the ability to induce differentiation of neuronal precursor cellswith two diferent origins. Separate transduction of adenovirusdelivering BDNF (BDNF-Ad) or NT3 (NT3-Ad) induced theneuronal differentiation in hippocampal and cortical precursor cells.Ad infected cells had longer neurites. In the early differentiationof hippocampal precursor cells, simultaneous infection of BDNF-Ad and NT3-Ad promoted further diferentiation and neuriteelongation compared with the separate infection of each virus.In contrast, simultaneous infection did not show the synergisticeffect in the cortical precursor cells, suggesting that theneurotrophins play distinct roles in diferent regions of the brain.However, the numbers of neurites and spines per diferentiatedcells were markedly increased in cortical as well as hippocampalelongation and formation of dendritic spine, when BDNF-Adand NT3-Ad were co-infected. These results sugest morestudies in the effect of a combinatorial use of neurotrophinson different sites of brain need to be carried out to developgene therapy protocols for neurodegenerative diseases.
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참고문헌 (26)
참고문헌 신청
Barnabe-Heider, F / 2003 / Endogenously produced neurotrophins regulate survival and differentiation of cortical progenitors via distinct signaling pathways 23 : 5149 ~ 5160
Davies / 1994 / The role of neurotrophins in the developing nervous system : 1334 ~ 1348
Friedman / 1990 / and NGF in the developing rat nervous system Parallel as well as reciprocal patterns of expression : 501 ~ 3 5 509
Henderson, C. E / 1996 / Role of neurotrophic factors in neuronal development 6 : 64 ~ 70
Hofer / 1990 / Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain : 2459 ~ 2464
Davies / 1994 / The role of neurotrophins in the developing nervous system : 1334 ~ 1348
Friedman / 1990 / and NGF in the developing rat nervous system Parallel as well as reciprocal patterns of expression : 501 ~ 3 5 509
Henderson, C. E / 1996 / Role of neurotrophic factors in neuronal development 6 : 64 ~ 70
Hofer / 1990 / Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain : 2459 ~ 2464
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