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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제10호
- 발행연도
- 2008.1
- 수록면
- 1,729 - 1,734 (6page)
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Chitosan, a cationic polysaccharide, has been widely used as a dietary supplement and in a variety of pharmacological and biomedical applications. The antifungal activity and mechanism of action of low molecular weight water-soluble chitosan (LMWS-chitosan) were studied in fungal cells and vesicles containing various compositions of fungal lipids. LMWS-chitosan showed strong antifungal activity against various pathogenic yeasts and hyphae-forming fungi but no hemolytic activity or cytotoxicity against mammalian cells. The degree of calcein leakage was assessed on the basis of lipid composition (PC/CH; 10:1, w/w). Our result showing that LMWS-chitosan interacts with liposomes demonstrated that chitosan induces leakage from zwitterionic lipid vesicles. Confocal microscopy revealed that LMWSchitosan was located in the plasma membrane. Finally, scanning electron microscopy revealed that LMWS-chitosan causes significant morphological changes on fungal surfaces.
Its potent antibiotic activity suggests that LMWS-chitosan is an excellent candidate as a lead compound for the development of novel anti-infective agents.
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참고문헌 (23)
참고문헌 신청
Alonso, M. J. / 2003 / The potential of chitosan in ocular drug delivery. J. Pharm / Pharmacol 55 : 1451 ~ 1463
Boman, H. G. / 1995 / Peptide antibiotics and their role in innate immunity. Annu. Rev / Immunol 13 : 61 ~ 92
Chae, S. Y. / 2005 / Influence of molecular weight on oral absorption of water soluble chitosans. J / Control Release 102 : 383 ~ 394
Illum, L. / 1998 / Chitosan and its use as a pharmaceutical excipient / Pharm. Res 15 : 1326 ~ 1331
Jeon, Y. J. / 2001 / Potential immuno-stimulating effect of antitumoral fraction of chitosan oligosaccharides. J / Chitin Chitosan 6 : 163 ~ 167
Boman, H. G. / 1995 / Peptide antibiotics and their role in innate immunity. Annu. Rev / Immunol 13 : 61 ~ 92
Chae, S. Y. / 2005 / Influence of molecular weight on oral absorption of water soluble chitosans. J / Control Release 102 : 383 ~ 394
Illum, L. / 1998 / Chitosan and its use as a pharmaceutical excipient / Pharm. Res 15 : 1326 ~ 1331
Jeon, Y. J. / 2001 / Potential immuno-stimulating effect of antitumoral fraction of chitosan oligosaccharides. J / Chitin Chitosan 6 : 163 ~ 167
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