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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제22권 제2호
- 발행연도
- 2012.1
- 수록면
- 274 - 282 (9page)
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초록· 키워드
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The object of this study was to assess the efficacy of Polycan from Aureobasidium pullulans SM-2001, which is composed mostly of beta-1,3-1,6-glucan, on osteoarthritis (OA)-induced by anterior cruciate ligament transection and partial medial meniscectomy (ACLT&PMM). Three different dosages of Polycan (85, 42.5, and 21.25 mg/kg)were orally administered once a day for 84 days to male rats a week after ACLT&PMM surgery. Changes in the circumference and maximum extension angle of each knee, and in cartilage histopathology were assessed using Mankin scores 12 weeks after Polycan administration. In addition, cartilage proliferation was evaluated using bromodeoxyuridine (BrdU). As the result of ACLT&PMM,classic OA was induced with increases in maximum extension angles, edematous knees changes, and capsule thickness, as well as decreases in chondrocyte proliferation,cartilages degenerative changes, and loss of articular cartilage. However, these changes (except for capsule thickness) were markedly inhibited in all Polycan- and diclofenac sodium-treated groups compared with OA control.
Although diclofenac sodium did not influence BrdU uptake,BrdU-immunoreactive cells were increased with all dosages of Polycan, which means that Polycan treatment induced proliferation of chondrocytes in the surface articular cartilage of the tibia and femur. The results obtained in this study suggest that 84 days of continuous oral treatment of three different dosages of Polycan led to lesser degrees of articular stiffness and histological cartilage damage compared with OA controls 91 days after OA inducement,suggesting that the optimal Polycan dosage to treat OA is 42.5 mg/kg based on the present study.
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참고문헌 (22)
참고문헌 신청
Appleton, C. T. / 2007 / Forced mobilization accelerates pathogenesis: Characterization of a preclinical surgical model of osteoarthritis / Arthritis Res. Ther 9 : R13 ~
Armstrong, S. / 1994 / The effects of intraarticular hyaluronan on cartilage and subchondral bone changes in an ovine model of early osteoarthritis / J. Rheumatol 21 : 680 ~
Arsever, C. L. / 1986 / Experimental osteoarthritis induced by selective myectomy and tendotomy / Arthritis Rheum 29 : 251 ~ 261
Badley, E. M. / 1994 / Relative importance of musculoskeletal disorders as a cause of chronic health problems, disability, and health care utilization: Findings from the 1990
Badley, E. M. / 1995 / The effect of osteoarthritis on disability and health care use in Canada / J. Rheumatol. Suppl 43 : 19 ~ 22
Armstrong, S. / 1994 / The effects of intraarticular hyaluronan on cartilage and subchondral bone changes in an ovine model of early osteoarthritis / J. Rheumatol 21 : 680 ~
Arsever, C. L. / 1986 / Experimental osteoarthritis induced by selective myectomy and tendotomy / Arthritis Rheum 29 : 251 ~ 261
Badley, E. M. / 1994 / Relative importance of musculoskeletal disorders as a cause of chronic health problems, disability, and health care utilization: Findings from the 1990
Badley, E. M. / 1995 / The effect of osteoarthritis on disability and health care use in Canada / J. Rheumatol. Suppl 43 : 19 ~ 22
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