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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제22권 제6호
- 발행연도
- 2012.1
- 수록면
- 814 - 817 (4page)
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초록· 키워드
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In the continued search for melanogenesis inhibitors from microbial metabolites, we found that the culture broth of Clitocybe sp. MKACC 53267 inhibited melanogenesis in B16F10 melanoma cells. The active component was purified by solvent extraction, silica gel chromatography,Sephadex LH-20 column chromatography, and finally by preparative HPLC. Its structure was determined as 5-pentyl-2-furaldehyde on the basis of the UV, NMR, and MS spectroscopic analysis. The 5-pentyl-2-furaldehyde potently inhibited melanogenesis in B16F10 cells with an IC50 value of 8.4 μg/ml, without cytotoxicity.
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참고문헌 (14)
참고문헌 신청
BAEK SEUNGHWA / 2006 / Idescarpin Isolated from the Fruits of Idesia polycarpa Inhibits Melanin Biosynthesis / Journal of Microbiology and Biotechnology 16 (5) : 667 ~ 672
Curto, E. V. / 1999 / Inhibition of mammalian melanocyte tyrosinase: In vitro comparisons of alkyl esters of gentisic acid with other putative inhibitors / Biochem. Pharmacol
Dooley, T. P. / 1994 / Development of an in vitro primary screen for skin depigmentation and antimelanoma agents / Skin Pharmacol 7 : 188 ~ 200
Hayashi, M. / 1981 / New nematicidal metabolites from a fungus, Irpex lacteus / Agric. Biol. Chem 45 : 1527 ~ 1529
KIM, WON-GON / 2005 / Terrein, a Melanin Biosynthesis Inhibitor, from Penicillium sp. 20135 / Journal of Microbiology and Biotechnology 15 (4) : 891 ~ 894
Curto, E. V. / 1999 / Inhibition of mammalian melanocyte tyrosinase: In vitro comparisons of alkyl esters of gentisic acid with other putative inhibitors / Biochem. Pharmacol
Dooley, T. P. / 1994 / Development of an in vitro primary screen for skin depigmentation and antimelanoma agents / Skin Pharmacol 7 : 188 ~ 200
Hayashi, M. / 1981 / New nematicidal metabolites from a fungus, Irpex lacteus / Agric. Biol. Chem 45 : 1527 ~ 1529
KIM, WON-GON / 2005 / Terrein, a Melanin Biosynthesis Inhibitor, from Penicillium sp. 20135 / Journal of Microbiology and Biotechnology 15 (4) : 891 ~ 894
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