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논문 기본 정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제20권 제2호
- 발행연도
- 2010.1
- 수록면
- 346 - 349 (4page)
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Coenzyme Q10 (CoQ10) production from Rhizobium radiobacter T6102 was monitored under various oxygen supply conditions by controlling the agitation speeds,aeration rates, and dissolved oxygen levels. As the results,the CoQ10 production was enhanced by limited oxygen supply. To investigate whether the CoQ10 production is associated with its physiological functions of electron carrier and antioxidant, the effects of sodium azide and hydrogen peroxide on the CoQ10 production were studied,showing that the CoQ10 contents were slightly enhanced with increasing sodium azide (up to 0.4 mM) and hydrogen peroxide (up to 10 μM) concentrations. These results suggest the plausible mechanism where the limited electron transfer stimulating the environments of limited oxygen supply and oxidative stress could accumulate the CoQ10, providing the relationship between the CoQ10 physiological functions and its regulation system.
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참고문헌 (19)
참고문헌 신청
Berndt, J. D / 2001 / Effects of chronic sodium azide on brain and muscle cytochrome oxidase activity: A potential model to investigate environmental contributions to neurode
Britta, S / 2000 / Ubiquinone limits oxidative stress in Escherichia coli / Microbiology 146 : 787 ~ 796
Choi, G.-S / 2005 / Restricted electron flux increases coenzyme Q10 production in Agrobacterium tumefaciens ATCC4452 / Process Biochem 40 : 3225 ~ 3229
Cluis, C. P / 2007 / Current prospects for the production of coenzyme Q10 in microbes / Trends Biotechnol 25 : 514 ~ 521
Do, T. Q / 1996 / Enhanced sensitivity of ubiquinone-deficient mutants of Saccharomyces cerevisiae to products of autoxidized polyunsaturated fatty acids / Proc. Natl. Acad. Sci. U
Britta, S / 2000 / Ubiquinone limits oxidative stress in Escherichia coli / Microbiology 146 : 787 ~ 796
Choi, G.-S / 2005 / Restricted electron flux increases coenzyme Q10 production in Agrobacterium tumefaciens ATCC4452 / Process Biochem 40 : 3225 ~ 3229
Cluis, C. P / 2007 / Current prospects for the production of coenzyme Q10 in microbes / Trends Biotechnol 25 : 514 ~ 521
Do, T. Q / 1996 / Enhanced sensitivity of ubiquinone-deficient mutants of Saccharomyces cerevisiae to products of autoxidized polyunsaturated fatty acids / Proc. Natl. Acad. Sci. U
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