지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제10호
- 발행연도
- 2015.1
- 수록면
- 1,640 - 1,647 (8page)
이용수
초록· 키워드
오류제보하기
We recently reported that the antimicrobial peptide Lumbricusin (NH2-RNRRWCIDQQA), isolated from the earthworm, increases cell proliferation in neuroblastoma SH-SY5Y cells. Here, we investigated whether Lumbricusin has neurotropic activity in mouse neural stem cells (MNSCs) and a protective effect in a mouse model of Parkinson’s disease (PD). In MNSCs isolated from mouse brains, Lumbricusin treatment significantly increased cell proliferation (up to 12%) and reduced the protein expression of p27Kip1 through proteasomal protein degradation but not transcriptional regulation. Lumbricusin inhibited the 6-OHDA-induced apoptosis of MNSCs, and also showed neuroprotective effects in a mouse PD model, ameliorating the motor impairments seen in the pole, elevated body swing, and rotation tests. These results suggest that the Lumbricusin-induced promotion of neural cell proliferation via p27Kip1 degradation has a protective effect in an experimental PD model. Thus, the antimicrobial peptide Lumbricusin could possibly be developed as a potential therapeutic agent for the treatment of PD.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Bo Ram Kang / 2012 / CopA3 peptide from Copris tripartitus induces apoptosis in human leukemia cells via a caspase-independent pathway / BMB Reports 45 (2) : 85 ~ 90
Chaudhry IB / 2012 / Minocycline benefits negative symptoms in early schizophrenia: a randomised doubleblind placebo-controlled clinical trial in patients on standard treatme
Chen LW / 2004 / Neurokinin peptides and neurokinin receptors as potential therapeutic intervention targets of basal ganglia in the prevention and treatment of Parkinson’s d
Dixit A / 2013 / Minocycline, levodopa and MnTMPyP induced changes in the mitochondrial proteome profile of MPTP and maneb and paraquat mice models of Parkinson's disease / B
Eggert A / 2000 / Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells / Oncogene 19 : 2043 ~ 2051
Chaudhry IB / 2012 / Minocycline benefits negative symptoms in early schizophrenia: a randomised doubleblind placebo-controlled clinical trial in patients on standard treatme
Chen LW / 2004 / Neurokinin peptides and neurokinin receptors as potential therapeutic intervention targets of basal ganglia in the prevention and treatment of Parkinson’s d
Dixit A / 2013 / Minocycline, levodopa and MnTMPyP induced changes in the mitochondrial proteome profile of MPTP and maneb and paraquat mice models of Parkinson's disease / B
Eggert A / 2000 / Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells / Oncogene 19 : 2043 ~ 2051
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Characterization of Antimicrobial Activity and Mechanism of Antimicrobial Peptide against Bacteria
한국미생물학회 학술대회논문집
2016 .04
-
Antimicrobial Cyclic Peptides for Plant Disease Control
The Plant Pathology Journal
2015 .03
-
Agathobaculum butyriciproducens Shows Neuroprotective Effects in a 6-OHDA-Induced Mouse Model of Parkinson’s Disease
Journal of Microbiology and Biotechnology
2022 .09
-
6-OHDA으로 유도한 파킨슨병 모델에서의 선퇴추출물의 행동장애 및 도파민 세포 사멸 억제 효과
한국환경과학회지
2023 .10
-
Antimicrobial and Antioxidant Peptide from Bacillus Strain CBS73 Isolated from Korean Food
조선자연과학논문집
2017 .01
-
Antimicrobial Activity and Action of Mechanism of Antimicrobial Peptide and Its Analog Peptides against Acinetobacter baumannii and Staphylococcus aureus
한국미생물학회 학술대회논문집
2019 .04
-
Antimicrobial Activity of Antimicrobial Peptide LPcin-YK3 Derived from Bovine Lactophoricin
Journal of Microbiology and Biotechnology
2018 .01
-
Antimicrobial Activity and Mechanism of Action of Red Sea Bream-derived Antimicrobial Peptide CAP2
한국미생물학회 학술대회논문집
2022 .10
-
Antimicrobial Peptides from Lactobacillus plantarum UTNGt2 Prevent Harmful Bacteria Growth on Fresh Tomatoes
Journal of Microbiology and Biotechnology
2019 .01
-
Antimicrobial and Antibiofilm Activities and Mechanisms of Action of Antimicrobial Peptides against Klebsiella pneumoniae
한국미생물학회 학술대회논문집
2019 .04
-
PD-1: A Negative Regulator of Phagocytosis by Tumour-Associated Macrophages in Colon Cancer
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2019 .12
-
Efficacy of Antimicrobial Peptide on Antibacterial, Anti-biofilm Activity
한국미생물학회 학술대회논문집
2016 .04
-
Development of a Novel Short Synthetic Antibacterial Peptide Derived from the Swallowtail Butterfly Papilio xuthus Larvae
Journal of Microbiology and Biotechnology
2020 .01
-
Asymmetric induced magnetic moment of top and bottom Pd layers in Pd/Co/Pd trilayer system
한국자기학회 학술연구발표회 논문개요집
2015 .05
-
A Study on Cell Selectivity and Anti-biofilm Activity of Antimicrobial Peptide by Residues Substitution
한국미생물학회 학술대회논문집
2019 .04
-
Antimicrobial Peptides (AMPs) with Dual Mechanisms: Membrane Disruption and Apoptosis
Journal of Microbiology and Biotechnology
2015 .01
-
Understanding the Roles of Host Defense Peptides in Immune Modulation: From Antimicrobial Action to Potential as Adjuvants
Journal of Microbiology and Biotechnology
2023 .03
-
Design and Engineering of Antimicrobial Peptides Based on LPcin- YK3, an Antimicrobial Peptide Derivative from Bovine Milk
Journal of Microbiology and Biotechnology
2018 .01
-
Bactericidal Activity and Mechanism of Action of Novel Antimicrobial Peptide SHP20 and Its Analog Peptides against Pseudomonas aeruginosa
한국미생물학회 학술대회논문집
2022 .10
-
Antiangiogenic Activity of the Lipophilic Antimicrobial Peptides from an Endophytic Bacterial Strain Isolated from Red Pepper Leaf
Molecules and Cells
2015 .03
이 논문의 저자 정보
최근 본 자료
댓글(0)
0