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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제4호
- 발행연도
- 2017.1
- 수록면
- 660 - 667 (8page)
이용수
초록· 키워드
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PineXol, extracted from Korean red pine bark, has beneficial effects, such as antioxidant, antiinflammatory, and antilipogenic activities in vitro. We tested the hypothesis that PineXol supplementation could have anti-obesity effects on mice fed a high-fat diet (HFD). Four-weekold male C57BL/6 mice were fed normal chow (18% kcal from fat) or a HFD (60% kcal from fat). HFD-fed animals were also subjected to PineXol treatment at a dose of 10 or 50 mg/kg body weight (BW) (PX10 or PX50, respectively) body weight. The body weight and body fat mass in the PX50 group were statistically lower than those in the HFD group (p < 0.05 and p < 0.001, respectively). The concentration of hepatic triglycerides, total cholesterol, and lowdensity lipoprotein cholesterol were reduced in the PX50 group compared with the HFD group (p < 0.01). Acetyl CoA carboxylase (p < 0.01), elongase of very long chain fatty acids 6 (p < 0.01), stearoyl CoA desaturase 1 (p < 0.05), microsomal triglyceride transfer protein (p < 0.01), and sterol regulatory element-binding protein 1 (p < 0.05) were significantly decreased in the PX50 group compared with that in the HFD group. In white adipose tissue, CCAATenhancer- binding protein alpha (p < 0.05), peroxisome proliferator-activated receptor gamma (p < 0.001), and perilipin (p < 0.01) were decreased in the PX50 group compared with those in the HFD group. Therefore, the current study implies the potential of PineXol for the prevention and/or amelioration of obesity, in part by inhibition of both hepatic lipid synthesis and adipogenesis in white adipose tissue.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Ballinger A / 2002 / Orlistat: its current status as an anti-obesity drug / Eur. J. Pharmacol 440 : 109 ~ 117
Bayeta E / 2000 / Pycnogenol inhibits generation of inflammatory mediators in macrophages / Nutr. Res 20 : 249 ~ 259
Biddinger SB / 2006 / From mice to men: insights into the insulin resistance syndromes / Annu. Rev. Physiol 68 : 123 ~ 158
Canali R / 2009 / The antiinflammatory pharmacology of Pycnogenol in humans involves COX-2 and 5-LOX mRNA expression in leukocytes / Int. Immunopharmacol 9 : 1145 ~ 1149
Das U / 2001 / Is obesity an inflammatory condition? / Nutrition 17 : 953 ~ 966
Bayeta E / 2000 / Pycnogenol inhibits generation of inflammatory mediators in macrophages / Nutr. Res 20 : 249 ~ 259
Biddinger SB / 2006 / From mice to men: insights into the insulin resistance syndromes / Annu. Rev. Physiol 68 : 123 ~ 158
Canali R / 2009 / The antiinflammatory pharmacology of Pycnogenol in humans involves COX-2 and 5-LOX mRNA expression in leukocytes / Int. Immunopharmacol 9 : 1145 ~ 1149
Das U / 2001 / Is obesity an inflammatory condition? / Nutrition 17 : 953 ~ 966
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