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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제2호
- 발행연도
- 2015.1
- 수록면
- 255 - 267 (13page)
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초록· 키워드
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Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of Johne’s disease, a chronic debilitating disease affecting ruminants worldwide. In the present study, we aimed to determine the major gene networks and pathways underlying the immune response to MAP infection using whole-blood cells, as well as provide the potential transcriptional markers for identifying the status of MAP infection. We analyzed the transcriptional profiles of wholeblood cells of cattle identified and grouped according to the presence of MAP-specific antibodies and the MAP shed by them. The grouping was based on the results obtained by ELISA and PCR analyses as follows: i) Test1 group: MAP-negative results obtained by ELISA and positive results obtained by PCR; ii) Test2 group: MAP-positive results obtained by ELISA and negative results obtained by PCR; iii) Test3 group: MAP-positive results obtained by ELISA and positive results obtained by PCR; iv) uninfected control: MAP-negative results obtained both by ELISA and PCR analysis. The results showed down-regulated production and metabolism of reactive oxygen species in the Test1 group, activation of pathways related to the host-defense response against MAP (LXR/RXR activation and complement system) in the Test2 and Test3 groups, and anti-inflammatory response (activation of IL-10 signaling pathway) only in the Test3 group. Our data indicate a balanced response that serves the immune-limiting mechanism while the host-defense responses are progressing.
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참고문헌 (21)
참고문헌 신청
Aly S / 2007 / Interferon-gamma-dependent mechanisms of mycobacteriainduced pulmonary immunopathology: the role of angiostasis and CXCR3-targeted chemokines for granuloma nec
Borelli V / 1999 / Myeloperoxidase exerts microbicidal activity against Mycobacterium tuberculosis / Infect. Immun 67 : 4149 ~ 4152
Chiodini RJ / 1984 / Possible role of mycobacteria in inflammatory boweldisease. 1. An unclassified Mycobacterium species isolated from patients with Crohns-disease / Digest.
Coffman F. / 2008 / Chitinase 3-Like-1 (CHI3L1): a putative disease marker at the interface of proteomics and glycomics / Crit. Rev. Clin. Lab. Sci 45 : 531 ~ 562
Collins MT / 1994 / Herd prevalence and geographic distribution of, and risk factors for, bovine paratuberculosis in Wisconsin / J. Am. Vet. Med. Assoc 204 : 636 ~ 641
Borelli V / 1999 / Myeloperoxidase exerts microbicidal activity against Mycobacterium tuberculosis / Infect. Immun 67 : 4149 ~ 4152
Chiodini RJ / 1984 / Possible role of mycobacteria in inflammatory boweldisease. 1. An unclassified Mycobacterium species isolated from patients with Crohns-disease / Digest.
Coffman F. / 2008 / Chitinase 3-Like-1 (CHI3L1): a putative disease marker at the interface of proteomics and glycomics / Crit. Rev. Clin. Lab. Sci 45 : 531 ~ 562
Collins MT / 1994 / Herd prevalence and geographic distribution of, and risk factors for, bovine paratuberculosis in Wisconsin / J. Am. Vet. Med. Assoc 204 : 636 ~ 641
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