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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 509 - 515 (7page)
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Photodynamic therapy(PDT) has advanced to clinical trials for the treatment of a variety of solid tumors and presents an alternative treatment option for tumors resistant to chemo-and/or radio-therapy. PDT is based on the combination of laser light of appropriate wavelength and energy to activate a systemically or locally applied photosensitizer that concentrates preferentially in malignant tissues. In this study, phototoxicity of laser EIT 21 was analysed in human osteosarcoma cell(HOS) and the second objective of this study was to determine the ability of laser EIT 21 to induce apoptosis
This study demonstrated that laser EIT 21 had a phototoxicity to HOS cells. In order to examinate whether cell death was induced by necrosis or apoptosis, variety of techniques which assess apoptosis were used. TUNEL assay showed only a few the positive reaction on condensed nuclei. It is hard to find condensed or fragmented nuclei on HOS cells irradiated with laser EIT 21 in Hemastat and AO/EB stain. By DNA electrophoresis, cells also did not show DNA degradation characteristic of apoptosis with a ladder pattern of DNA fragments. Apoptosis-related factors were analyzed by western blotting. The expression of p53 was constant and cells irradiated with laser did not show the caspase-3 and PARP degradation, therefore we suggest that p53 and caspase-3 are not involved in laser-induced cell death.
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참고문헌 (30)
참고문헌 신청
Agarwal ML / 1991 / Photodynamic therapy induces rapid cell death by apoptosis in L5178Y mouse lymphoma cells : 5993 ~ 5996
Ali SM / 2003 / Mechanisms of action of phenanthroperylenequinones in photodynamic therapy 22 (6) : 1187 ~ 1191
Canti G / 1995 / Efficacy of photodynamic therapy against doxorubicin-resistant murine tumors 93 (2) : 255 ~ 259
Chan WH / 2000 / Apoptotic signalling cascade in photosensitized human epidermal carcinoma A431 cells: involvement of singlet oxygen, c-Jun N-terminal kinase, caspase-3 and
Decaudin D / 1998 / Mitochondria in chemotherapy-induced apoptosis a prospective novel target of cancer therapy 12 (1) : 141 ~ 152
Ali SM / 2003 / Mechanisms of action of phenanthroperylenequinones in photodynamic therapy 22 (6) : 1187 ~ 1191
Canti G / 1995 / Efficacy of photodynamic therapy against doxorubicin-resistant murine tumors 93 (2) : 255 ~ 259
Chan WH / 2000 / Apoptotic signalling cascade in photosensitized human epidermal carcinoma A431 cells: involvement of singlet oxygen, c-Jun N-terminal kinase, caspase-3 and
Decaudin D / 1998 / Mitochondria in chemotherapy-induced apoptosis a prospective novel target of cancer therapy 12 (1) : 141 ~ 152
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