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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 453 - 459 (7page)
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초록· 키워드
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Introduction: Ameloblastic carcinoma is a rare malignant lesion, and may arise from either carcinoma ex-ameloblastoma or de novo carcinoma.
Aberrant promoter hypermethylation of the tumor-associated genes leading to their inactivation is a common event in many cancer types. The p16/CDKN2/INK4A gene and p16 5 protein are involved directly in regulating the cell cycles. Cadherins are cell adhesion molecules that modulate the epithelial phenotype and regulate tumor invasion. The aim of this study was to evaluate the roles of p16 and E-cadherin methylation and loss of p16 and E-cadherin expression in the malignant transformation of an ameloblastoma.
Materials and Methods: Eight cases of ameloblastoma, including 4 benign ameloblastomas without recurrence, 2 benign ameloblastomas with recurrence and 2 carcinoma ex-ameloblastomas, were examined. The promoter hypermethylation profile of the p16 and E-cadherin genes was studied using methylation-specific polymerase chain reaction (MSP) and immunohistochemical staining for p16 and E-cadherin expression.
Results:1) Aberrant CpG island methylation of the p16 gene was detected in 3 of the 4 benign ameloblastomas without recurrence and 1 of the 2 benign ameloblastomas with recurrence.
2) Aberrant CpG island methylation of the E-cadherin gene was found in 1 of the 4 benign ameloblastomas without recurrence.
3) A loss of p16 expression was noted in 1 of 4 benign ameloblastomas without recurrence and 1 of 2 carcinoma ex-ameloblastomas.
4) A loss of E-cadherin expression was noted in 2 of the 4 benign ameloblastomas without recurrence, 1 of the 2 benign ameloblastomas with recurrence and 2 of the 2 carcinoma ex-ameloblastomas.
5) A loss of p16 expression was observed in 1 of the 4 cases showing aberrant methylation of the p16 gene.
6) A loss of E-cadherin expression was observed in 3 benign ameloblastoma case showing aberrant methylation of the E-cadherin gene.
Conclusion: These results suggest that loss of E-cadherin expression related to the other genetic pathway (not methylation) might be an adjuvant indicator predicting the malignant transformation of an ameloblastoma. However, the number of samples in this study was too small and the relationship between the treatment methods and clinical course were not defined. Therefore, further study will be needed.
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참고문헌 (18)
참고문헌 신청
Abiko Y / 2007 / Ameloblastic carcinoma ex-ameloblastoma: report of a case-possible involvement of CpG island hypermethylation of the p16 gene in malignant transformation / O
Auerkari EI / 2006 / Methylation of tumor suppressor genes p16(INK4a), p7(Kip1) and E-cadherin in carcinogenesis / Oral Oncol 42 : 5 ~ 13
Barnes L / 2005 / World Health Organization classification of tumours: pathology and genetics of head and neck tumours / International Agency for Research on Cancer Press
Baylin SB / 2001 / Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer / Hum Mol Genet 10 : 687 ~ 692
Chen Q / 2004 / Promoter methylation regulates cadherin switching in squamous cell carcinoma / Biochem Biophys Res Commun 315 : 850 ~ 856
Auerkari EI / 2006 / Methylation of tumor suppressor genes p16(INK4a), p7(Kip1) and E-cadherin in carcinogenesis / Oral Oncol 42 : 5 ~ 13
Barnes L / 2005 / World Health Organization classification of tumours: pathology and genetics of head and neck tumours / International Agency for Research on Cancer Press
Baylin SB / 2001 / Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer / Hum Mol Genet 10 : 687 ~ 692
Chen Q / 2004 / Promoter methylation regulates cadherin switching in squamous cell carcinoma / Biochem Biophys Res Commun 315 : 850 ~ 856
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