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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 94 - 100 (7page)
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Purpose: This study was done to confirm the role of NF-κB in cisplatin-induced apoptosis of oral squamous cell carcinoma.
Materials and Methods: Five cell lines originated from different oral cancer patients were tested for the apoptosis by the treatment of cisplatin.
These cells showed different degree of cisplatin-resistance and the order is OSCC-2> OSCC-3> OSCC-5> OSCC-1> OSCC-4. OSCC-2 and OSCC-4
cells were assayed for the apoptosis by measuring DNA fragmentation and TUNEL staining after cisplatin treatment. While OSCC-4 cells showed
apoptosis, OSCC-2 cells showed no or very slight apoptosis by cisplatin treatment. Next, It was determined whether NF-κB activation is required in
mediating cisplatin-induced apoptosis of OSCC-4 .
Result: The result was that elevated NF-κB activity mediated cisplatin-induced apoptosis.
Conclusion: In conclusion, these findings suggest that NF-κB activation is essential to cisplatin-induced apoptosis and it may be involved in cisplatin
resistance in OSCC cells.
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참고문헌 (27)
참고문헌 신청
/ / Activation of programmed cell death by anticanceragents cisplatin as a model system : 8 275 ~ 9 80
/ / Cellular pharmacology of cisplatin per-spectives on mechanisms of acquired resistance : 35 ~ 43
/ 1995 / Transcription factor DNA binding activity inPC12 cells undergoing apoptosis after glucose deprivation 26 : 137 ~ 140
/ 1995 / Tumor necrosis factors alpha and beta protect neurons against amy-loid beta-peptide toxicity evidence for involvement of a kappa B-binding factor and attenuation of
/ 1996 / An essential role for NF-kappaB in preventingTNF-alpha-induced cell death 1 : 782 ~ 784
/ / Cellular pharmacology of cisplatin per-spectives on mechanisms of acquired resistance : 35 ~ 43
/ 1995 / Transcription factor DNA binding activity inPC12 cells undergoing apoptosis after glucose deprivation 26 : 137 ~ 140
/ 1995 / Tumor necrosis factors alpha and beta protect neurons against amy-loid beta-peptide toxicity evidence for involvement of a kappa B-binding factor and attenuation of
/ 1996 / An essential role for NF-kappaB in preventingTNF-alpha-induced cell death 1 : 782 ~ 784
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