지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 396 - 402 (7page)
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Introduction: Epidermal growth factor is a single-chain polypeptide consisting of 53 amino acids with potent mitogenic activity that stimulates the proliferation of a range of normal and neoplastic cells through an interaction with its specific receptor (epidermal growth factor receptor, EGFR). This interaction plays a key role in tumor progression including the induction of tumor cell proliferation. An increased EGFR copy number have been associated with a favorable response to EGFR tyrosine kinase inhibitors therapy. In contrast, K-ras mutations tend to predict a poor response to such therapy.
The aim of this study was to determine the correlation between the clinicopathological factors and the up-regulation of EGFR expression and Kras mutations in oral squamous cell carcinoma.
Materials and Methods: This study examined the immunohistochemical staining of EGFR, K-ras mutation detection with peptide nucleic acid (PNA)-based real-time polymerase chain reaction (PCR) clamping in 20 specimens from 20 patients with oral squamous cell carcinoma.
Results: 1. In the immunohistochemical study of poorly differentiated and invasive oral squamous cell carcinoma, a high level of EGFR staining was observed. The correlation between immunohistochemical EGFR expression and histological differentiation, as well as the tumor size of the specimens was significant (Pearson correlation analysis, significance [r] >0.5, P<0.05). 2. In PNA-based real-time PCR clamping analysis, a K-ras mutation was not detected in all specimens.
Conclusion: These findings suggest that the up-regulation of the EGFR may play a role in the progression and invasion of oral squamous cell carcinoma that is, independent of a K-ras mutation.
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참고문헌 (23)
참고문헌 신청
Carpenter G / 1986 / Epidermal growth factor, its receptor, and related proteins / Exp Cell Res 164 : 1 ~ 10
Carvalho AL / 2003 / Sites of recurrence in oral and oropharyngeal cancers according to the treatment approach / Oral Dis 9 : 112 ~ 118
Carvalho AL / 2004 / Trends of oral and oropharyngeal cancer survival over five decades in 3267 patients treated in a single institution / Oral Oncol 40 : 71 ~ 76
Christensen ME / 1992 / Epidermal growth factor receptor expression on oral mucosa dysplastic epithelia and squamous cell carcinomas / Eur Arch Otorhinolaryngol 249 : 243 ~ 2
Cohen S / 1962 / Isolation of submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal / J Biol Chem 237 : 1544 ~ 1562
Carvalho AL / 2003 / Sites of recurrence in oral and oropharyngeal cancers according to the treatment approach / Oral Dis 9 : 112 ~ 118
Carvalho AL / 2004 / Trends of oral and oropharyngeal cancer survival over five decades in 3267 patients treated in a single institution / Oral Oncol 40 : 71 ~ 76
Christensen ME / 1992 / Epidermal growth factor receptor expression on oral mucosa dysplastic epithelia and squamous cell carcinomas / Eur Arch Otorhinolaryngol 249 : 243 ~ 2
Cohen S / 1962 / Isolation of submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal / J Biol Chem 237 : 1544 ~ 1562
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