지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 699 - 706 (8page)
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초록· 키워드
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Objective To evaluate whether the administration of vaginal natural micronized progesterone is associated with reduction of recurrent preterm birth (PTB) in women with prior history of spontaneous PTB.
Methods We retrospectively evaluated the obstetric and neonatal outcomes of all women with history of spontaneous PTB that delivered from January 2008 through April 2012. Spontaneous PTB was defined as PTB before 37 weeks of gestation due to spontaneous preterm labor or preterm premature rupture of membranes. Pregnancies with multiple gestation and those who received cerclage operation during previous or current pregnancy were excluded. Patients in the progesterone group were instructed to self-administer 100 or 200 mg vaginal micronized natural progesterone capsule. We evaluated the difference in recurrent PTB rate between the progesterone group (n = 73) and the non-user group (n = 158).
Results The incidence of recurrent spontaneous PTB before 37 weeks’ gestation was significantly lower in the progesterone group than the non-user group (21.9% vs. 43.0%, P=0.002). Multivariate analysis showed that progesterone therapy was associated with a decrease in the incidence of recurrent PTB before 37 weeks’ gestation (odds ratio, 0.382; 95% confidence interval, 0.169-0.863; P=0.021) independent of confounding variables.
Conclusion Micronized vaginal progesterone supplement therapy was associated with a reduction of recurrent PTB risk in women with previous spontaneous PTB history.
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참고문헌 (23)
참고문헌 신청
Cetingoz E / 2011 / Progesterone effects on preterm birth in high-risk pregnancies: a randomized placebo-controlled trial / Arch Gynecol Obstet 283 : 423 ~ 429
DeFranco EA / 2007 / Vaginal progesterone is associated with a decrease in risk for early preterm birth and improved neonatal outcome in women with a short cervix: a seconda
Fonseca EB / 2007 / Progesterone and the risk of preterm birth among women with a short cervix / N Engl J Med 357 : 462 ~ 469
Goffinet F. / 2005 / Primary predictors of preterm labour / BJOG 112 (1) : 38 ~ 47
Goldenberg RL / 2008 / Epidemiology and causes of preterm birth / Lancet 371 : 75 ~ 84
DeFranco EA / 2007 / Vaginal progesterone is associated with a decrease in risk for early preterm birth and improved neonatal outcome in women with a short cervix: a seconda
Fonseca EB / 2007 / Progesterone and the risk of preterm birth among women with a short cervix / N Engl J Med 357 : 462 ~ 469
Goffinet F. / 2005 / Primary predictors of preterm labour / BJOG 112 (1) : 38 ~ 47
Goldenberg RL / 2008 / Epidemiology and causes of preterm birth / Lancet 371 : 75 ~ 84
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