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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 333 - 339 (7page)
이용수
초록· 키워드
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Objective The purpose of this study was to investigate the expression of the D6 decoy receptor that can bind chemokines and targetthem for degradation, resulting in inhibition of inflammation in placentas from preeclamptic and normal pregnancies.
Methods The current study was carried out in 35 pregnant women (23 patients with preeclampsia and 12 healthy, normotensivepregnant women) during the third trimester of pregnancy. The expressions of D6 decoy receptor in the placenta weredetermined with real time reverse transcriptase polymerase chain reaction and western blotting.
Results The mRNA and protein of D6 decoy receptor were detected in all of placentas from preeclamptic and normal pregnancies.
Placental D6 decoy receptor mRNA expression was significantly lower in patients with preeclampsia than in patients withnormal pregnancies. Western blot analyses revealed decreased protein expression in cases of preeclampsia.
Conclusion The expression of the D6 decoy receptor in preeclamptic placentas was significantly lower than in normal placentas. Furtherstudies are needed to clarify the underlying mechanisms that link decreased expression of placental D6 decoy receptor andpreeclampsia.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
[학술지(정기간행물)] -
Barak S. / 2007 / Evidence of periopathogenic microorganisms in placentas of women with preeclampsia / J Periodontol 78 : 670 ~ 676
Boggess KA. / 2003 / Maternal periodontal disease is associated with an increased risk for preeclampsia / Obstet Gynecol 101 : 227 ~ 231
Bonecchi R. / 2004 / Differential recognition and scavenging of native and truncated macrophage-derived chemokine(macrophage-derived chemokine/CC chemokine ligand 22)by the D
Borzychowski AM. / 2006 / Inflammation and pre-eclampsia / Semin Fetal Neonatal Med 11 : 309 ~ 316
Barak S. / 2007 / Evidence of periopathogenic microorganisms in placentas of women with preeclampsia / J Periodontol 78 : 670 ~ 676
Boggess KA. / 2003 / Maternal periodontal disease is associated with an increased risk for preeclampsia / Obstet Gynecol 101 : 227 ~ 231
Bonecchi R. / 2004 / Differential recognition and scavenging of native and truncated macrophage-derived chemokine(macrophage-derived chemokine/CC chemokine ligand 22)by the D
Borzychowski AM. / 2006 / Inflammation and pre-eclampsia / Semin Fetal Neonatal Med 11 : 309 ~ 316
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