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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 441 - 447 (7page)
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Objective To investigate the expression of messenger RNA (mRNA) for membrane type-2 matrix metalloproteinases (MT2-MMPs ) and MT3-MMP and compare their expression pattern in women with severe endometriosis and normal controls.
Methods Quantitative competitive polymerase chain reaction was performed to evaluate the mRNA expression of MT2-MMP and MT3-MMP in endometrium from 36 women with severe endometriosis and 52 women without endometriosis throughout the menstrual cycle.
Results Eutopic endometrium from women with endometriosis expressed higher levels of MT3-MMP than that from normal women in secretory phase (P < 0.05). MT2-MMP expression from eutopic endometrium showed no signifi cant differences between patients with endometriosis and controls.
Conclusion These results suggest that eutopic endometrium from patients with endometriosis may be more proteolytic, angiogenic and prone to growth because of greater MT3-MMP expression than endometrium from women without endometriosis. Thus, increased proteolytic and angiogenic activities may be one of the explanations of the pathogenesis of endometriosis.
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참고문헌 (22)
참고문헌 신청
/ 1985
Chung HW / 2002 / Matrix metalloproteinase-2, membranous type 1 matrix metalloproteinase, and tissue inhibitor of metalloproteinase-2 expression in ectopic and eutopic endom
Collette T / 2004 / Evidence for an increased release of proteolytic activity by the eutopic endometrial tissue in women with endometriosis and for involvement of matrix met
Cramer DW / 1986 / The relation of endometriosis to menstrual characteristics, smoking, and exercise / JAMA 255 : 1904 ~ 1908
Goffi n F / 2003 / Expression pattern of metalloproteinases and tissue inhibitors of matrix-metalloproteinases in cycling human endometrium / Biol Reprod 69 : 976 ~ 984
Chung HW / 2002 / Matrix metalloproteinase-2, membranous type 1 matrix metalloproteinase, and tissue inhibitor of metalloproteinase-2 expression in ectopic and eutopic endom
Collette T / 2004 / Evidence for an increased release of proteolytic activity by the eutopic endometrial tissue in women with endometriosis and for involvement of matrix met
Cramer DW / 1986 / The relation of endometriosis to menstrual characteristics, smoking, and exercise / JAMA 255 : 1904 ~ 1908
Goffi n F / 2003 / Expression pattern of metalloproteinases and tissue inhibitors of matrix-metalloproteinases in cycling human endometrium / Biol Reprod 69 : 976 ~ 984
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