지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 295 - 302 (8page)
이용수
초록· 키워드
오류제보하기
ObjectiveTo estimate the incidence of falsely elevated risk of ovarian malignancy algorithm (ROMA) in a group of women with pathologically confirmed endometrioma and to investigate the associated factors.
MethodsOne hundred premenopausal women surgically diagnosed with ovarian endometrioma were selected. Preoperative clinical, laboratory, and surgical characteristics were compared between the elevated-risk group (ROMA-premenopausal value, ≥7.4%) and normal-risk group (ROMA-premenopausal value, <7.4%).
ResultsElevated ROMA was observed in 15 women (false positive rate, 15%). Excluding one woman with known chronic renal failure, we compared the characteristics of 99 women between the elevated-risk group (n=14) and the normal-risk group (n=85). None of the clinical and surgical variables distinguished the two groups. Serum level of CA 125 >82.3 U/mL and serum level of human epididymis protein 4 (HE4) >46 pmol/L could predict an elevated ROMA test with a statistical significance. When serum level of HE4 ≤46 pmol/L, none of the women showed an elevated ROMA test, regardless of serum level of CA 125; however, 55.6% of the women showed an elevated ROMA test when serum level of HE4 >46 pmol/L and CA 125 ≤82.3 U/mL and all women showed an elevated ROMA test when serum level of HE4 >46 pmol/L and CA 125 >82.3 U/mL.
ConclusionThe incidence of falsely elevated ROMA was 15% in the group of women with pathologically confirmed endometrioma. Interpretation of the ROMA results should be cautious when serum level of HE4 >46 pmol/L and CA 125 >82.3 U/mL in women with suspicious ovarian endometrioma.
목차
등록된 정보가 없습니다.
참고문헌 (12)
참고문헌 신청
Moore RG / 2008 / The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass / Gynecol Oncol 108:402~408
Moore RG / 2009 / A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass / Gynecol Oncol 112:40~46
Moore RG / 2010 / Comparison of a novel multiple marker assay vs the Risk of Malignancy Index for the prediction of epithelial ovarian cancer in patients with a pelvic mass / Am J Obstet Gynecol 203:228.e1~228.e6
Jacob F / 2011 / No benefit from combining HE4 and CA125 as ovarian tumor markers in a clinical setting / Gynecol Oncol 121:487~491
Stukan M / 2015 / Usefulness of diagnostic indices comprising clinical, sonographic, and biomarker data for discriminating benign from malignant ovarian masses / J Ultrasound Med 34:207~217
Moore RG / 2009 / A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass / Gynecol Oncol 112:40~46
Moore RG / 2010 / Comparison of a novel multiple marker assay vs the Risk of Malignancy Index for the prediction of epithelial ovarian cancer in patients with a pelvic mass / Am J Obstet Gynecol 203:228.e1~228.e6
Jacob F / 2011 / No benefit from combining HE4 and CA125 as ovarian tumor markers in a clinical setting / Gynecol Oncol 121:487~491
Stukan M / 2015 / Usefulness of diagnostic indices comprising clinical, sonographic, and biomarker data for discriminating benign from malignant ovarian masses / J Ultrasound Med 34:207~217
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Comparison of HE4, CA125, and Risk of Ovarian Malignancy Algorithm in the Prediction of Ovarian Cancer in Korean Women
Journal of Korean Medical Science
2015 .01
-
MMP3 in Comparison to CA 125, HE4 and the ROMA Algorithm in Differentiation of Ovarian Tumors
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Distinguishing benign from malignant pelvic mass utilizing an algorithm with HE4, menopausal status, and ultrasound findings
Journal of Gynecologic Oncology
2015 .01
-
Clinical Usefulness of Cancer Antigen (CA) 125, Human Epididymis 4, and CA72-4 Levels and Risk of Ovarian Malignancy Algorithm Values for Diagnosing Ovarian Tumors in Korean Patients With and Without Endometriosis
Annals of Laboratory Medicine
2020 .01
-
Ob난소암진단에서 Human Epididymis Protein 4의 유용성 및 한국인의 정상 참고범위
Laboratory Medicine Online
2016 .01
-
Menstrual characteristics in Korean women with endometriosis: a pilot study
Obstetrics & Gynecology Science
2018 .01
-
Prognostic Impact of Elevation of Cancer Antigen 15-3 (CA15-3) in Patients With Early Breast Cancer With Normal Serum CA15-3 Level
Journal of Breast Cancer
2023 .04
-
Diagnostic Accuracy of the Risk of Ovarian Malignancy Algorithm in Clinical Practice at a Single Hospital in Korea
Annals of Laboratory Medicine
2019 .01
-
Tissue CA125 and HE4 Gene Expression Levels Offer Superior Accuracy in Discriminating Benign from Malignant Pelvic Masses
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Dietary pattern and risk of endometrioma in Korean women: a case-control study
Obstetrics & Gynecology Science
2021 .01
-
Serum Anti-Müllerian Hormone Levels before Surgery in Patients with Ovarian Endometriomas Compared to Other Benign Ovarian Cysts
대한폐경학회지
2015 .01
-
Abnormally high level of CA-19-9 in a benign ovarian cyst
Obstetrics & Gynecology Science
2015 .01
-
Clinical experience of long-term use of dienogest after surgery for ovarian endometrioma
Obstetrics & Gynecology Science
2018 .01
-
Could surgical management improve the IVF outcomes in infertile women with endometrioma?: a review
Obstetrics & Gynecology Science
2019 .01
-
Usefulness of subtraction pelvic magnetic resonance imaging for detection of ovarian endometriosis
Journal of Yeungnam Medical Science
2020 .01
-
Recurrence, Reoperation, Pregnancy Rates, and Risk Factors for Recurrence after Ovarian Endometrioma Surgery: Long-Term Follow-Up of 756 Women
Yonsei Medical Journal
2023 .03
-
The meaning of anti-Mullerian hormone levels in patients at a high risk of poor ovarian response
Clinical and experimental reproductive medicine : CERM
2016 .01
-
Associations of Serum Isoflavone, Adiponectin and Insulin Levels with Risk for Epithelial Ovarian Cancer: Results of a Case-control Study
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Awareness of Ovarian Cancer Risk Factors among Women in Malaysia: A Preliminary Study
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Effect of second-line surgery on in vitro fertilization outcome in infertile women with ovarian endometrioma recurrence after primary conservative surgery for moderate to severe endometriosis
Obstetrics & Gynecology Science
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0