지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 629 - 635 (7page)
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초록· 키워드
오류제보하기
Objective We investigated the in vivo tocolytic effect of Clostridium botulinum toxin A (BoNT/A) on mifepristone-induced preterm labor in rats.
Methods On day 17 of gestation, an incision was made to expose the uterus, and BoNT/A (normal saline or 20 units) was injected into the uterine horns. On day 18, mifepristone was used to induce uterine contractions. Electrical activity of uterine contractions was measured via electromyography on day 19.
Results In rats treated with 20 units of BoNT/A, the amplitude of uterine contractions was significantly decreased by 45.2 ± 18.4 (P<0.05) from baseline, respectively. The total duration of uterine contractions was significantly decreased by 51.7 ± 7.9 (P<0.01), respectively. The frequency of contraction bursts after treatment with 20 units of BoNT/A was decreased by 5.6 ± 16.3 from the baseline (P=0.4).
Conclusion In rats undergoing mifepristone-induced preterm labor, BoNT/A significantly inhibited uterine contractility. The decrease in uterine activity was mainly caused by a decline in the duration and intensity rather than frequency of uterine contractions.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Anotayanonth S / 2004 / Betamimetics for inhibiting preterm labour / Cochrane Database Syst Rev (4) : 004352 ~
Beck S / 2010 / The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity / Bull World Health Organ 88 : 31 ~ 38
Brisinda G / 2003 / Gastrointestinal smooth muscles and sphincters spasms: treatment with botulinum neurotoxin / Curr Med Chem 10 : 603 ~ 623
Buhimschi C / 1998 / Uterine activity during pregnancy and labor assessed by simultaneous recordings from the myometrium and abdominal surface in the rat / Am J Obstet Gynec
Buhimschi CS / 2003 / The forces of labour / Fetal Matern Med Rev 14 : 273 ~ 307
Beck S / 2010 / The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity / Bull World Health Organ 88 : 31 ~ 38
Brisinda G / 2003 / Gastrointestinal smooth muscles and sphincters spasms: treatment with botulinum neurotoxin / Curr Med Chem 10 : 603 ~ 623
Buhimschi C / 1998 / Uterine activity during pregnancy and labor assessed by simultaneous recordings from the myometrium and abdominal surface in the rat / Am J Obstet Gynec
Buhimschi CS / 2003 / The forces of labour / Fetal Matern Med Rev 14 : 273 ~ 307
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