지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 106 - 111 (6page)
이용수
초록· 키워드
오류제보하기
Objective Women with Lynch syndrome have an increased risk of developing colorectal and gynecologic malignancies such as endometrial cancer. Complex hyperplasia has about a 30% risk of developing into endometrial cancer. The aim of this study was to determine the genetic risk for developing endometrial cancer by immunohistochemical staining of premalignant lesions for mutL homolog 1, mutS homolog 2, mutS homolog 6, and postmeiotic segregation increased 2.
Methods Twenty cases (n=20) were selected from among patients with available sample blocks for analysis. Clinical information was obtained from medical chart review. Immunohistochemical staining was performed for all of the tumor blocks. Staining was scored based on the intensity (intensity score 0–3) .
Results Among the 20 cases of complex endometrial hyperplasia, 11 (55%) patients showed loss of expression of at least one of the following proteins: mutL homolog 1, mutS homolog 2, mutS homolog 6, or postmeiotic segregation increased 2. Seven (35%) patients were negative for the expression of two or more proteins, and one patient (5%) was negative for the expression of all four proteins.
Conclusion More than half of the patients showed loss of expression of at least one mismatch repair protein in our study population. Genetic risk counseling and further tests are recommended for these patients.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Bronner CE. / 1994 / Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer / Nature 368 : 258 ~ 261
Burgart LJ. / 2005 / Testing for defective DNA mismatch repair in colorectal carcinoma : a practical guide / Arch Pathol Lab Med 129 : 1385 ~ 1389
Dietmaier W. / 1997 / Diagnostic microsatellite instability : definition and correlation with mismatch repair protein expression / Cancer Res 57 : 4749 ~ 4756
Emons G. / 2000 / Hormonal interactions in endometrial cancer / Endocr Relat Cancer 7 : 227 ~ 242
Fishel R. / 1993 / The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer / Cell 75 : 1027 ~ 1038
Burgart LJ. / 2005 / Testing for defective DNA mismatch repair in colorectal carcinoma : a practical guide / Arch Pathol Lab Med 129 : 1385 ~ 1389
Dietmaier W. / 1997 / Diagnostic microsatellite instability : definition and correlation with mismatch repair protein expression / Cancer Res 57 : 4749 ~ 4756
Emons G. / 2000 / Hormonal interactions in endometrial cancer / Endocr Relat Cancer 7 : 227 ~ 242
Fishel R. / 1993 / The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer / Cell 75 : 1027 ~ 1038
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Endometrial cancer arising from atypical complex hyperplasia: The significance in an endometrial biopsy and a diagnostic challenge
Obstetrics & Gynecology Science
2015 .01
-
Risk Factors Associated with Endometrial Pathology in Premenopausal Breast Cancer Patients Treated with Tamoxifen
Yonsei Medical Journal
2020 .01
-
Relations of Platelet Indices with Endometrial Hyperplasia and Endometrial Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Endometrial adenocarcinoma in a 13-year-old girl
Obstetrics & Gynecology Science
2016 .01
-
Non-atypical endometrial hyperplasia: risk factors for occult endometrial atypia and malignancy in patients managed with hysterectomy
Obstetrics & Gynecology Science
2021 .01
-
Clinicopathologic Characteristics and Causes of Postmenopausal Bleeding in Older Patients
Annals of geriatric medicine and research
2018 .01
-
Comparison of Diagnostic Accuracies of Serum HE-4 Levels and 3D Power Doppler Angiography Parameters between Benign Endometrial Pathologies and Endometrial Cancer
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Rate of premalignant and malignant endometrial lesion in “low-risk” premenopausal women with abnormal uterine bleeding undergoing endometrial biopsy
Obstetrics & Gynecology Science
2021 .11
-
Case Report of Menopausal Woman Diagnosed with Endometrial Cancer after Colon Cancer with Germline Mutation in MSH6 in Korea
대한폐경학회지
2017 .01
-
Do Leukocyte and Platelet Counts Have Benefit for ＼Preoperative Evaluation of Endometrial Cancer?
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
The significance of sonographically thickened endometrium in asymptomatic postmenopausal women
Obstetrics & Gynecology Science
2019 .01
-
Wound Complications after Laparotomy for Endometrial Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
The gate-keeping role of surgeons with regard to endometrial cancers in Lynch syndrome
Journal of Gynecologic Oncology
2017 .01
-
C-kit Mutations in Endometrial Cancer: Correlation with Tumor Histologic Type
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Endometrial polyp surveillance in premenopausal breast cancer patients using tamoxifen
Obstetrics & Gynecology Science
2017 .01
-
Trends and characteristics of fertility-sparing treatment for atypical endometrial hyperplasia and endometrial cancer in Japan: a survey by the Gynecologic Oncology Committee of the Japan Society of Obstetrics and Gynecology
Journal of Gynecologic Oncology
2023 .05
-
Endometrial evaluation with transvaginal ultrasonography for the screening of endometrial hyperplasia or cancer in premenopausal and perimenopausal women
Obstetrics & Gynecology Science
2016 .01
-
Nationwide Comparison of Surgical and Oncologic Outcomes in Endometrial Cancer Patients Undergoing Robotic, Laparoscopic, and Open Surgery: A Population-Based Cohort Study
Cancer Research and Treatment
2021 .01
-
Endometrial cancer occurence five years after breast cancer in BRCA2 mutation patient
Obstetrics & Gynecology Science
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0