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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 170 - 177 (8page)
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초록· 키워드
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Objective: This study was done to evaluate whether perioperative propranolol (ß-blocker) in ovarian cancer patients undergoing debulking surgery reduced perioperative tumor growth induced by surgical stress.
Methods: This was a prospective randomized single institution analysis. The primary objective was to compare the changes in CA 125 level (changes between preoperation day 2 and postoperative day 7). As a study arm, patients received a low dose of propranolol 40 mg/day (4×10 mg) starting two days before surgery and 40 mg twice daily for three days following surgery.
Results: Twenty-two patients were enrolled and 16 were evaluable for efficacy. The drug was well tolerated. The mean decrease of CA 125 during the seven perioperative days was 83.1±8.9% in the propranolol group and 72.4±14.7% in the placebo group. The difference was statistically significant (P=0.044). The change of C-reactive protein, cortisol, and anxiety score (State-Trait Anxiety Inventory-X1) were not different between the two groups.
Conclusion: This preliminary result is the first to directly test the role of perioperative propranolol on tumor growth. Even with the small sample size and short term use of the drug, perioperative propranolol was effective in reducing tumor burden (as measured by CA 125) suggesting its potential benefits in decreasing perioperative tumor growth.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Abramovitch R / 1999 / Stimulation of tumour growth by wound-derived growth factors / Br J Cancer 79 : 1392 ~ 1398
Bernabe DG / 2011 / Stress hormones increase cell proliferation and regulates interleukin-6 secretion in human oral squamous cell carcinoma cells / Brain Behav Immun 25 : 57
Eschwege P / 1995 / Haematogenous dissemination of prostatic epithelial cells during radical prostatectomy / Lancet 346 : 1528 ~ 1530
Hofer SO / 1999 / The effect of surgical wounding on tumour development / Eur J Surg Oncol 25 : 231 ~ 243
Kerros C / 2010 / Reduction of cell proliferation and potentiation of Fas-induced apoptosis by the selective kappa-opioid receptor agonist U50 488 in the multiple myeloma LP
Bernabe DG / 2011 / Stress hormones increase cell proliferation and regulates interleukin-6 secretion in human oral squamous cell carcinoma cells / Brain Behav Immun 25 : 57
Eschwege P / 1995 / Haematogenous dissemination of prostatic epithelial cells during radical prostatectomy / Lancet 346 : 1528 ~ 1530
Hofer SO / 1999 / The effect of surgical wounding on tumour development / Eur J Surg Oncol 25 : 231 ~ 243
Kerros C / 2010 / Reduction of cell proliferation and potentiation of Fas-induced apoptosis by the selective kappa-opioid receptor agonist U50 488 in the multiple myeloma LP
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