지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 357 - 366 (10page)
이용수
초록· 키워드
오류제보하기
ObjectiveThis study was designed to review the screening performance of combined test at the Ewha Womans University Mokdong hospital.
MethodsAll women admitted for routine antenatal care between January 1st 2008 and December 31st 2012 with a known pregnancy outcome were included in this study, totaling 1,156 women with singleton pregnancies presenting at 10 to 13 weeks of gestation. Women were offered screening using a combination of maternal serum pregnancy-associated plasma protein-A, free β-human chorionic gonadotropin and fetal nuchal translucency thickness. Those with an estimated risk of ≥1 in 250 of carrying a fetus with trisomy 21 or ≥1 in 300 risk of trisomy 18 were offered genetic counseling with the option of an invasive diagnostic test.
ResultsThe median of gestational age was 11+3 weeks, the median of crown-rump length was 47.1 mm, and the median age of the women was 31 years. The detection rate was 80% for trisomy 21 (4 of 5) and 100% for trisomy 13 and 18 (all 2). The false-positive rate was 7.73% for trisomy 21 and 1.21% for trisomy 18.
ConclusionThis study was the first large population study performed with the aim of analyzing the performance of the combined test in Korea. This study demonstrated that the detection rates and other figures of the first trimester combined test are comparable to the results reported in other papers worldwide. Consequently, if strict conditions for good screening outcomes are achieved, the first trimester combined test might well be the earliest detectable screening, improving detection rates without increasing karyotyping or economic and other implications that inevitably ensue.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
ACOG Committee on Practice Bulletins / 2007 / ACOG Practice Bulletin No. 77: screening for fetal chromosomal abnormalities / Obstet Gynecol 109:217~227
Schuchter K / 2002 / The first trimester ‘combined test’ for the detection of Down syndrome pregnancies in 4939unselected pregnancies / Prenat Diagn 22:211~215
Wald NJ / 1997 / Combining ultrasound and biochemistry in first-trimester screening for Down’s syndrome / Prenat Diagn 17:821~829
Spencer K / 2000 / One stop clinic for assessment of risk for fetal anomalies : a report of the first year of prospective screening for chromosomal anomalies in the first trimester / BJOG 107:1271~1275
Spencer K / 2003 / Screening for chromosomal abnormalities in the first trimester using ultrasound and maternal serum biochemistry in a one-stop clinic : a review of three years prospective experience / BJOG 110:281~286
Schuchter K / 2002 / The first trimester ‘combined test’ for the detection of Down syndrome pregnancies in 4939unselected pregnancies / Prenat Diagn 22:211~215
Wald NJ / 1997 / Combining ultrasound and biochemistry in first-trimester screening for Down’s syndrome / Prenat Diagn 17:821~829
Spencer K / 2000 / One stop clinic for assessment of risk for fetal anomalies : a report of the first year of prospective screening for chromosomal anomalies in the first trimester / BJOG 107:1271~1275
Spencer K / 2003 / Screening for chromosomal abnormalities in the first trimester using ultrasound and maternal serum biochemistry in a one-stop clinic : a review of three years prospective experience / BJOG 110:281~286
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