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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한산부인과학회 Obstetrics & Gynecology Science Obstetrics & Gynecology Science 제61권 제1호
발행연도
2018.1
수록면
63 - 70 (8page)

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ObjectiveIn terms of efficacy, several previous studies have shown that the success rate in inhibiting preterm labor was not different between magnesium sulfate and ritodrine. However, there is a paucity of information regarding the efficacy of both medications after consideration of intra-amniotic infection, which is one of the most important prognostic factors in patients of threatened preterm birth. The objective of this study was to compare the efficacy and safety of magnesium sulfate with that of ritodrine in preterm labor. MethodsIn this retrospective cohort study, we included patients who were admitted and treated with either ritodrine or magnesium sulfate with the diagnosis of preterm labor at 24–33.6 weeks of gestational age between January 2005 to April 2015. Patients were divided into 2 groups according to the first-used tocolytics (ritodrine group and magnesium sulfate group). We compared the efficacy and prevalence of side effect in each group. The efficacy of both tocolytics was evaluated in terms of preterm delivery within 48 hours, 7 days, or 37 weeks of gestation and need for 2nd line therapy. ResultsA total number of 201 patients were enrolled including 177 cases in ritodrine group and 24 cases in magnesium sulfate group. The efficacy of both tocolytics (preterm delivery within 48 hours, 7 days, or 37 weeks of gestation and need for 2nd line therapy) was not different between the 2 groups of cases. In multivariate analysis, gestational age at treatment, twin gestation, intra-amniotic infection and maternal C-reactive protein (CRP) was associated with treatment failure (preterm delivery within 48 hours), but the type of tocolytics was not significantly associated with treatment failure. The type of side effect was different in the 2 groups, but the frequency of total adverse effect, need for discontinuation of therapy because of maternal adverse effect, and severe adverse effect were not different between the two groups of cases. ConclusionThe efficacy and safety of magnesium sulfate was similar to ritodrine, and can be a substitute tocolytics. Additionally, failure of tocolytic therapy was determined by gestational age at treatment, twin gestation, intra-amniotic infection, and maternal CRP, not by the type of tocolytics.

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참고문헌 (14)

참고문헌 신청
김종현 / 2001 / Magnesium sulfate (Magroseⓡ), Ritodrine Hydrochloride (Yutoparⓡ)와 Nifedipine (Adalatⓡ)의 조기진통 억제효과 및 안정성에 대한 비교연구 / Obstetrics & Gynecology Science 44(6):1165~1170 google schola Jorgensen JS / 2014 / Preterm labor: current tocolytic options for the treatment of preterm labor / Expert Opin Pharmacother 15:585~588 Crossref Canadian Preterm Labor Investigators Group / 1992 / Treatment of preterm labor with the beta-adrenergic agonist ritodrine / N Engl J Med 327:308~312 Crossref Haram K / 2015 / Tocolysis for acute preterm labor: does anything work / J Matern Fetal Neonatal Med 28:371~378 Crossref American College of Obstetricians / 2010 / Committee opinion no. 455: magnesium sulfate before anticipated preterm birth for neuroprotection / Obstet Gynecol 115:669~671 Crossref

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