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학술저널
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대한안과학회 Korean Journal of Ophthalmology Korean Journal of Ophthalmology 제29권 제3호
발행연도
2015.1
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190 - 194 (5page)

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Purpose: To compare pain scores of patients during intravitreal 27-gauge bevacizumab and 30-gauge ranibizumab injection procedures. Methods: Seventy eyes of 70 patients who had not previously undergone intravitreal anti-vascular endothelial growth factor therapy were included in this study. Thirty-five patients received ranibizumab and 35 patients received bevacizumab. The diagnoses of the patients were: 27 age related macular degeneration, 15 diabetic macular edema, 9 diabetic vitreous hemorrhage, 6 central retinal vein occlusion, 11 branch retinal vein occlusion and 2 central serous chorioretinopathy. Bevacizumab (1.25 mg/0.05 mL) was injected into the vitreous cavity using a 27-gauge needle, and ranibizumab (0.5 mg/0.05 mL) was injected with 30-gauge needle. Patients were asked just after the injection to rate their perceived pain during the injection using the visual analogue scale (VAS) of 0 (no pain) to 10 (unbearable/ worst pain). The average of these scores was used as the primary outcome. Results: The VAS pain scores in the ranibizumab and bevacizumab groups were 1.06 ± 0.91 (range, 0 to 3) and 1.94 ± 1.55 (range, 0 to 7), respectively, a significant difference (p = 0.005). Patients <65 and ≥65 years of age in both the ranibizumab and bevacizumab groups were then compared. For patients <65, there was a significant difference in the average VAS pain scores between groups (p = 0.003). However, for patients ≥65 years, there was not a significant difference in the average VAS pain scores between groups (p = 0.238). Female and male patients in both ranibizumab and bevacizumab groups were also compared. For female patients, there was a significant difference in the average VAS pain scores between groups (p = 0.016), although not for male patients (p = 0.078). Conclusions: Thirty-gauge intravitreal injection is more comfortable than 27-gauge injection. Injection of bevacizumab with 30-gauge needle syringes may be more tolerable for patients.
#Key Words: Bevacizumab #Intravitreal injections #Pain #Ranibizumab #Visual analogue scale

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참고문헌 (19)

참고문헌 신청
Aslankurt M / 2014 / Pain and cooperation in patients having dominant-side or nondominant-side phacoemulsification / J Cataract Refract Surg 40 : 199 ~ 202 google schola Avery RL / 2006 / Intravitreal bevacizumab (Avastin) in the treatment of proliferative diabetic retinopathy / Ophthalmology 113 : 1695 ~ google schola Chen D / 2014 / Monitor corneal epithelial healing under bandage contact lens using ultrahigh-resolution optical coherence tomography after pterygium surgery / Eye Contact L google schola Eaton AM / 2013 / Assessment of novel guarded needle to increase patient comfort and decrease injection time during intravitreal injection / Ophthalmic Surg Lasers Imaging R google schola Green-Simms AE / 2011 / Survey of intravitreal injection techniques among retinal specialists in the United States / Am J Ophthalmol 151 : 329 ~ 332 google schola

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