지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 361 - 367 (7page)
이용수
초록· 키워드
오류제보하기
It became possible to see all the expressed genes present in a cell (transcriptome) at once using microarray. We have applied microarray technology to various studies regarding allergic diseases. Although we and others have discovered various novel molecules crucially involved in the pathogenesis of the disease, transcriptome assay is now expected as a tool for understanding the whole molecule balancing, i.e., system biology. Here I introduce examples of our trials
for understanding the whole functional roles of a certain cell type related to allergy as has been published in the web database. In the near future, we will be able to construct human inflammatory cell models in silico (in a computer) by analyzing integrative information regarding the genome, transcriptome and proteome of mast cells and can test our hypothesis without performing in vitro testing.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
/ / Galli SJ. Mast cells as a source of both preformed and immunologically inducible TNF-α/cachectin. Nature 1990 : 274 ~ 6
/ / Ishizaka T. Effects of ADP-ribosylation of GTP-binding protein by pertussis toxin on immunoglobulin E-dependent and -independent histamine release from mast cells and ba
/ / et al. Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4 and IL-6 in human allergic mucosa
/ / et al. Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines. J Exp Med. 1989 : 245 ~ 57
/ / et al. Voltage-gated potassium channels regulate calcium- dependent pathways involved in human T lymphocyte activation. J Exp Med 1993 : 637 ~ 45
/ / Ishizaka T. Effects of ADP-ribosylation of GTP-binding protein by pertussis toxin on immunoglobulin E-dependent and -independent histamine release from mast cells and ba
/ / et al. Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4 and IL-6 in human allergic mucosa
/ / et al. Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines. J Exp Med. 1989 : 245 ~ 57
/ / et al. Voltage-gated potassium channels regulate calcium- dependent pathways involved in human T lymphocyte activation. J Exp Med 1993 : 637 ~ 45
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