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자료유형
학술저널
저자정보
저널정보
대한천식알레르기학회(구 대한알레르기학회) 천식 및 알레르기 천식 및 알레르기 제25권 제1호
발행연도
2005.1
수록면
45 - 51 (7page)

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Background: There are still some controversies in the progression and the effects of long term anti-inflammatory treatment on the cough variant asthma and idiopathic chronic cough. Objective: This study was aimed to see whether the airway hyper-responsiveness would persist or worsen in case of relapsing cough after stopping the anti-inflammatory therapy in cough variant asthma and idiopathic chronic cough. Method: Twenty two patients with cough variant asthma (group A) who revisited the hospital due to chronic cough after over two years of discontinuation of treatment were retrospectively studied and compared with 10 patients with idiopathic chronic cough (group B). Optionally, we defined the aggravation of airway hyper-responsiveness when the percent decrease of PC20 over 30%.Result: The initial and follow up mean PC20 of the patients with group A was 14.5±7.6 mg/mL and 19.6±13.4 mg/mL and that of the patients with group B was 43.6±7.9 mg/mL and 31.5±16.5 mg/mL (P>0.05). The change of mean PC20 was greater in group B (-12.1 mg/mL) than in group A (5 mg/mL). Forty percent of group B showed more aggravation of the airway hyper-responsiveness in compared with 27% of group A. Conclusion: We observed that airway hyper-responsiveness was aggravated in some patients of both of cough variant asthma and idiopathic chronic cough groups. It suggests the importance of the serial follow up of airway hyper-responsiveness in those groups.

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