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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 1 - 8 (8page)
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초록· 키워드
Naïve CD4+ helper T (Th) cells, upon activation by antigen-presenting cells (APC), differentiate into different types of effecter cells that are characterized by their distinct cytokine production profiles and immune regulatory functions. The Th1/Th2 paradigm implies the existence of 2 different, mutually regulated CD4+ T helper subsets: Th1cells, driving cell-mediated immune responses involved in tissue damage and intracellular parasite infestation and Th2cells that mediate IgE production and are particularly involved in eosinophilic inflammation, allergy and the clearance of helminthic infestation. A third member of the T helper set, IL-17-producing CD4+ T cells, now called Th17 cells, were recently described as a distinct lineage that does not share developmental pathways with either Th1 or Th2 cells. The Th17 subset has been linked to autoimmune disorders, being able to produce IL-17, IL-17F and IL-21.
This review article summarizes the most recent discovery of the cytokine-mediated regulation and transcriptional programming of Th17 cells and their role in different immune responses and diseases.
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