지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 131 - 139 (9page)
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초록· 키워드
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Background: Atopic dermatitis (AD) is the initial step of allergic march that progresses to airway allergic disease.
There has been much interest in the interruption of the allergic march, but the results are not promising. CpG oligodeoxynucleotide (ODN) has been reported to have both preventive and therapeutic effects on the development of asthma in mouse models.
Objective: To identify the development of airway inflammation after having atopic dermatitis-like skin lesions induced by topical application of Dermatophagoides farinae (Df), and to evaluate the preventive effect of CpG ODN on the development of airway inflammation.
Method: We injected 5μg of Df intradermally 8 times for 2 weeks into 8-week-old NC/Nga mice and then challenged them with 3 times of Df intranasally. CpG ODN with or without Df was injected subcutaneously before airway challenge.
Airway hyperreactivity was determined by the change inenhanced pause (Penh) during methacholine provocation.
Lung tissue and bronchoalveolar lavage specimens were evaluated.
Result: Topical Df application induced AD-like skin lesion microscopically, but not macroscopically. NC/Nga mice with topical Df application developed more severe airway inflammation upon intranasal Df challenge than those with topical PBS application. However, the mice with CpG ODN injection before airway challenge showed reduced airway inflammation.
The levels of Df-specific IgG1 were increased in the mice with both topical Df application and intranasal Df challenge but were decreased in the mice with CpG ODN injection.
Conclusion: These results suggest that CpG may inhibit the development of airway inflammation from those with previous AD-like skin lesions induced by Df.
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참고문헌 (20)
참고문헌 신청
Clark RA / 1989 / Aeroallergen contact can exacerbate atopic dermatitis: patch tests as a diagnostic tool / J Am Acad Dermatol 21 : 863 ~ 869
Creticos PS / 2006 / Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis / N Engl J Med 355 : 1445 ~ 1455
Fonseca DE / 2009 / Use of CpG oligonucleotides in treatment of asthma and allergic disease / Adv Drug Deliv Rev 61 : 256 ~ 262
He R / 2007 / Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge / Proc Natl Acad Sci USA 104 : 15817 ~ 15822
He R / 2009 / Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13 / J Allergy Clin Immunol 124 : 761 ~ 770.
Creticos PS / 2006 / Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis / N Engl J Med 355 : 1445 ~ 1455
Fonseca DE / 2009 / Use of CpG oligonucleotides in treatment of asthma and allergic disease / Adv Drug Deliv Rev 61 : 256 ~ 262
He R / 2007 / Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge / Proc Natl Acad Sci USA 104 : 15817 ~ 15822
He R / 2009 / Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13 / J Allergy Clin Immunol 124 : 761 ~ 770.
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