지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 246 - 251 (6page)
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초록· 키워드
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The current evidence supports a role of gut colonization in promoting and maintaining a balanced immune response during early life. Increasingly, epidemiologic and clinical data support the hypothesis that perturbation in the gastrointestinal microflora due to antibiotic use and dietary differences in ‘industrialized’ countries disrupt normal microflora-mediated immunological tolerance in the mucosa, leading to an increase in the prevalence of allergic diseases.
However, there has not been fully adequate longitudinal study of the relation between the infant gut microflora, the development of allergic diseases and the changes of lifestyles. The consensus of opinion is currently still lacking.
However, a complex interplay among a host’s immune response,characteristics of the gut microflora, a genetic background and the range of exposures become apparent. Even if at this time, practical implications cannot be deduced directly from these findings, there is a high potential for the development of novel preventive and therapeutic strategies in the future based on the concept of the microflora hypothesis.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Adlerberth I / 2007 / Gut microbiota and development of atopic eczema in 3 European birth cohorts / J Allergy Clin Immunol 120 : 343 ~ 350
Bezirtzoglou E / 1997 / The intestinal microflora during the first weeks of life / Anaerobe 3 : 173 ~ 177
Ege MJ / 2011 / Exposure to environmental microorganisms and childhood asthma / N Engl J Med 364 : 701 ~ 709
Giwercman C / 2010 / Increased risk of eczema but reduced risk of early wheezy disorder from exclusive breast-feeding in high-risk infants / J Allergy Clin Immunol 125 : 866
Kalliomaki M / 2001 / Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing / J Allergy Clin Immunol 107 : 129 ~ 134
Bezirtzoglou E / 1997 / The intestinal microflora during the first weeks of life / Anaerobe 3 : 173 ~ 177
Ege MJ / 2011 / Exposure to environmental microorganisms and childhood asthma / N Engl J Med 364 : 701 ~ 709
Giwercman C / 2010 / Increased risk of eczema but reduced risk of early wheezy disorder from exclusive breast-feeding in high-risk infants / J Allergy Clin Immunol 125 : 866
Kalliomaki M / 2001 / Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing / J Allergy Clin Immunol 107 : 129 ~ 134
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