Plasma cells are usually considered short-lived plasma cells.
This view is changing because plasma cells can survive for a long time in bone marrow. Long-lived plasma cells may be important in allergy because of the persistence of immunoglobulin E in allergic animal models after immune suppression. Allergic therapies efficiently control allergic symptoms but do not provide a cure, especially in adults.
Elimination of long-lived plasma cells that secrete specific immunoglobulin E may provide a cure in allergic patients.
The purpose of this review is to describe the creation of long-lived plasma cells and their importance in allergic diseases.
Plasma cells are usually considered short-lived plasma cells.
This view is changing because plasma cells can survive for a long time in bone marrow. Long-lived plasma cells may be important in allergy because of the persistence of immunoglobulin E in allergic animal models after immune suppression. Allergic therapies efficiently control allergic symptoms but do not provide a cure, especially in adults.
Elimination of long-lived plasma cells that secrete specific immunoglobulin E may provide a cure in allergic patients.
The purpose of this review is to describe the creation of long-lived plasma cells and their importance in allergic diseases.