지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 238 - 244 (7page)
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초록· 키워드
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Background:Vitamin E is widely known to be one of the reactive oxygen species (ROS) scavengers and a drug that can easily be obtained, and it has been shown to attenuate the pain responses induced by various causes in animal pain models. Thus, this experiment was conducted to assess the antinociceptive effects of vitamin E by comparing intraperitoneal and intrathecal injections in rats subjected to the formalin test.
Methods:After the intraperitoneal and intrathecal injections of vitamin E were carried out, respectively (IP: 500 mg/kg, 1 g/kg, and 2 g/kg, IT: 3 mg/kg, 10 mg/kg, and 30 mg/kg), the formalin test was perfumed. As soon as 5% formalin was injected into left hind paw, the number of flinches induced by pain was measured at 5-minute intervals for 1 hour.
Results:Formalin injected into the left hind paw induced biphasic nociceptive behavior in all animals. Intraperitoneal injection of vitamin E diminished the nociceptive behavior in a dose-dependent manner during the early and late phase. Intrathecal vitamin E diminished nociceptive behavior dose dependently during the late phase but showed no significant difference in the early phase.
Conclusions:Vitamin E attenuated acute nociception when it was injected systemically, while both systemic and intrathecal injection produced analgesia in a rat model of formalin-induced hyperalgesia.
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참고문헌 (22)
참고문헌 신청
Balazs L / 1994 / Evidence of an oxidative challenge in the Alzheimer's brain / Neurochem Res 19 : 1131 ~ 1137
Coderre TJ / 1990 / Central nervous system plasticity in the tonic pain response to subcutaneous formalin injection / Brain Res 535 : 155 ~ 158
Cuesta MC / 1999 / Opposite modulation of capsaicin-evoked substance P release by glutamate receptors / Neurochem Int 35 : 471 ~ 478
Gao X / 2005 / Enhancement of NMDA receptor phosphorylation of the spinal dorsal horn and nucleus gracilis neurons in neuropathic rats / Pain 116 : 62 ~ 72
Gao X / 2007 / Reactive oxygen species (ROS) are involved in enhancement of NMDA- receptor phosphorylation in animal models of pain / Pain 131 : 262 ~ 271
Coderre TJ / 1990 / Central nervous system plasticity in the tonic pain response to subcutaneous formalin injection / Brain Res 535 : 155 ~ 158
Cuesta MC / 1999 / Opposite modulation of capsaicin-evoked substance P release by glutamate receptors / Neurochem Int 35 : 471 ~ 478
Gao X / 2005 / Enhancement of NMDA receptor phosphorylation of the spinal dorsal horn and nucleus gracilis neurons in neuropathic rats / Pain 116 : 62 ~ 72
Gao X / 2007 / Reactive oxygen species (ROS) are involved in enhancement of NMDA- receptor phosphorylation in animal models of pain / Pain 131 : 262 ~ 271
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