지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 14 - 20 (7page)
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초록· 키워드
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Background:Nefopam, a non-opiate analgesic, has been regarded as a substance that reduces the requirement for morphine, but conflicting results have also been reported. The inhibition of monoamine reuptake is a mechanism of action for the analgesia of nefopam. The spinal cord is an important site for the action of monoamines however, the antinociceptive effect of intrathecal nefopam was not clear. This study was performed to examine the antinociceptive effect of intrathecal (i.t.) nefopam and the pattern of pharmacologic interaction with i.t. morphine in the formalin test.
Methods:Male Sprague-Dawley rats were implanted with an i.t. catheter, and were randomly treated with a vehicle, nefopam, or morphine. Formalin was injected into the hind-paw 10 min. after an i.t. injection of the above experiment drugs. After obtaining antinociceptive ED50 of nefopam and morphine, the mixture of nefopam and morphine was tested for the antinociceptive effect in the formalin test at a dose of 1/8, 1/4, 1/2 of ED50, or ED50 of each drug followed by an isobolographic analysis.
Results:Intrathecal nefopam significantly reduced the flinching responses in both phases of the formalin test in a dose-dependent manner. Its effect, however, peaked at a dose of 30 mg in phase 1 (39.8% of control) and 10 mg during phase 2 (37.6% of control). The isobolograhic analysis indicated an additive interaction of nefopam and morphine during phase 2, and a synergy effect in antinociception during phase 1.
Conclusions:This study demonstrated that i.t. nefopam produces an antinociceptive effect in formalin induced pain behavior during both phases of the formalin test, while interacting differently with i.t. morphine, synergistically during phase 1, and additively during phase 2.
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참고문헌 (24)
참고문헌 신청
Aveline C / 2009 / Postoperative analgesia and early rehabilitation after total knee replacement: a comparison of continuous low-dose intravenous ketamine versus nefopam / E
Beaver WT / 1977 / A comparison of the analgesic effect of intramuscular nefopam and morphine in patients with postoperative pain / J Clin Pharmacol 17 : 579 ~ 591
Beloeil H / 2004 / The median effective dose of nefopam and morphine administered intravenously for postoperative pain after minor surgery: a prospective randomized double-b
Bernatzky G / 1986 / Intrathecal injection of codeine, buprenorphine, tilidine, tramadol and nefopam depresses the tail-flick response in rats / Eur J Pharmacol 120 : 75 ~ 8
Buritova J / 2002 / Effects of nefopam on the spinal nociceptive processes: a c-Fos protein study in the rat / Eur J Pharmacol 441 : 67 ~ 74
Beaver WT / 1977 / A comparison of the analgesic effect of intramuscular nefopam and morphine in patients with postoperative pain / J Clin Pharmacol 17 : 579 ~ 591
Beloeil H / 2004 / The median effective dose of nefopam and morphine administered intravenously for postoperative pain after minor surgery: a prospective randomized double-b
Bernatzky G / 1986 / Intrathecal injection of codeine, buprenorphine, tilidine, tramadol and nefopam depresses the tail-flick response in rats / Eur J Pharmacol 120 : 75 ~ 8
Buritova J / 2002 / Effects of nefopam on the spinal nociceptive processes: a c-Fos protein study in the rat / Eur J Pharmacol 441 : 67 ~ 74
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