지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 102 - 108 (7page)
이용수
초록· 키워드
오류제보하기
Background: Nefopam is a non-opioid, non-steroidal analgesic drug with fewer adverse effects than narcotic analgesics and nonsteroidal anti-inflammatory drugs, and is widely used for postoperative pain control. Because nefopam sometimes causes side effects such as nausea, vomiting, somnolence, hyperhidrosis and injection-related pain, manufacturers are advised to infuse it slowly, over a duration of 15 minutes. Nevertheless, pain at the injection site is very common. Therefore, we investigated the effect of warmed carrier fluid on nefopam injection-induced pain.Methods: A total of 48 patients were randomly selected and allocated to either a control or a warming group. Warming was performed by diluting 40 mg of nefopam in 100 ml of normal saline heated to 31–32°C using two fluid warmers. The control group was administered 40 mg of nefopam dissolved in 100 ml of normal saline stored at room temperature (21–22°C) through the fluid warmers, but the fluid warmers were not activated.Results: The pain intensity was lower in the warming group than in the control group (P ＜ 0.001). The pain severity and tolerance measurements also showed statistically significant differences between groups (P ＜ 0.001). In the analysis of vital signs before and after the injection, the mean blood pressure after the injection differed significantly between the groups (P = 0.005), but the heart rate did not. The incidence of hypertension also showed a significant difference between groups (P = 0.017).Conclusions: Use of warmed carrier fluid for nefopam injection decreased injection-induced pain compared to mildly cool carrier fluid. (Korean J Pain 2018; 31: 102-8)
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Girard P / 2016 / Nefopam analgesia and its role in multimodal analgesia: a review of preclinical and clinical studies / Clin Exp Pharmacol Physiol 43:3~12
Kim YM / 2014 / Slow injection of nefopam reduces pain intensity associated with intravenous injection: a prospective randomized trial / J Anesth 28:399~406
Dordoni PL / 1994 / Effect of ketorolac, ketoprofen and nefopam on platelet function / Anaesthesia 49:1046~1049
Bhatt AM / 1981 / Respiratory and metabolic effects of oral nefopam in human volunteers / Br J Clin Pharmacol 11:209~211
Evans MS / 2008 / Nefopam for the prevention of postoperative pain: quantitative systematic review / Br J Anaesth 101:610~617
Kim YM / 2014 / Slow injection of nefopam reduces pain intensity associated with intravenous injection: a prospective randomized trial / J Anesth 28:399~406
Dordoni PL / 1994 / Effect of ketorolac, ketoprofen and nefopam on platelet function / Anaesthesia 49:1046~1049
Bhatt AM / 1981 / Respiratory and metabolic effects of oral nefopam in human volunteers / Br J Clin Pharmacol 11:209~211
Evans MS / 2008 / Nefopam for the prevention of postoperative pain: quantitative systematic review / Br J Anaesth 101:610~617
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