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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 279 - 289 (11page)
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초록· 키워드
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Variation in human skin and hair color is the most notable aspect of human variability and several studies in evolution, genetics and developmental biology contributed to explain the mechanisms underlying human skin pigmentation, which is responsible for differences in skin color across the world’s populations. Despite skin pigmentation is primarily related to melanocytes functionality, the surrounding keratinocytes and extracellular matrix proteins and fibroblasts in the underlying dermal compartment actively contribute to cutaneous homeostasis. Many autocrine/paracrine secreted factors and cell adhesion mechanisms involving both epidermal and dermal constituents determine constitutive skin pigmentation and, whenever deregulated, the occurrence of pigmentary disorders. In particular, an increased expression of such mediators and their specific receptors frequently lead to hyperpigmentary conditions, such as in melasma and in solar lentigo, whereas a defect in their expression/release is related to hypopigmented disorders, as seen in vitiligo. All these interactions underline the relevant role of pigmentation on human evolution and biology.
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참고문헌 (88)
참고문헌 신청
Fitzpatrick TB. / 1963 / The epidermal melanin unit system / Dermatol Wochenschr 147:481~489
Yamaguchi Y. / 2009 / Physiological factors that regulate skin pigmentation / Biofactors 35:193~199
Staricco RJ. / 1957 / Quantitative and qualitative data on the pigment cells of adult human epidermis / J Invest Dermatol 28:33~45
Alaluf S. / 2003 / Ethnic variation in tyrosinase and TYRP1 expression in photoexposed and photoprotected human skin / Pigment Cell Res 16:35~42
Alaluf S. / 2002 / Ethnic variation in melanin content and composition in photoexposed and photoprotected human skin / Pigment Cell Res 15:112~118
Yamaguchi Y. / 2009 / Physiological factors that regulate skin pigmentation / Biofactors 35:193~199
Staricco RJ. / 1957 / Quantitative and qualitative data on the pigment cells of adult human epidermis / J Invest Dermatol 28:33~45
Alaluf S. / 2003 / Ethnic variation in tyrosinase and TYRP1 expression in photoexposed and photoprotected human skin / Pigment Cell Res 16:35~42
Alaluf S. / 2002 / Ethnic variation in melanin content and composition in photoexposed and photoprotected human skin / Pigment Cell Res 15:112~118
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