개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 55 - 60 (6page)
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초록· 키워드
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Background: Psoriasis is a chronic inflammatory disease. In the treatment of psoriasis, cyclosporine is commonly prescribed systemic agents. However, long-term use of cyclosporine is not recommended because of side effects such as nephrotoxicity or hypertension. Objective: To ascertain the improved safety of rotational therapy using cyclosporine and methotrexate, we investigated the frequency of abnormal results in laboratory test after long term rotational therapy using cyclosporine and methotrexate. Methods: From January 2009 to June 2014, patients who were treated with cyclosporine or methotrexate were enrolled. The clinical data and usage of medications were reviewed. Laboratory tests were conducted before starting the treatment and regularly follow- up. The occurrences of any laboratory abnormalities during the treatments were investigated. Results: A total of 21 psoriatic patients were enrolled. The mean of medication period and cumulative dose of cyclosporine and methotrexate were 497.81±512.06 days and 115.68±184.34 g in cyclosporine and 264.19±264.71 days and 448.71±448.63 mg in methotrexate. Laboratory abnormalities were found in total two patients after rotational therapy: two patients (9.5%) in aspartate aminotransferase/alanine aminotransferase and one patient (4.8%) in uric acid. No laboratory abnormalities were found in renal function test. Conclusion: We found that the rotational approaches using cyclosporine and methotrexate reduced the possibility of the development of nephrotoxicity.
In addition to other advantage such as quick switching from one agent to another, the rotational therapy using cyclosporine and methotrexate can minimize the adverse events during the systemic treatment of chronic plaque psoriasis.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Berth-Jones J / 1997 / Treatment of psoriasis with intermittent short course cyclosporin (Neoral). A multicentre study / Br J Dermatol 136 : 527 ~ 530
Colombo MD / 2013 / Cyclosporine regimens in plaque psoriasis: an overview with special emphasis on dose, duration, and old and new treatment approaches / ScientificWorldJour
Ellis CN / 1991 / Cyclosporine for plaque-type psoriasis. Results of a multidose, double-blind trial / N Engl J Med 324 : 277 ~ 284
Garcia-Bustinduy M / 2004 / Safety of long-term treatment with cyclosporin A in resistant chronic plaque psoriasis: a retrospective case series / J Eur Acad Dermatol Venereo
Greaves MW / 1995 / Treatment of psoriasis / N Engl J Med 332 : 581 ~ 588
Colombo MD / 2013 / Cyclosporine regimens in plaque psoriasis: an overview with special emphasis on dose, duration, and old and new treatment approaches / ScientificWorldJour
Ellis CN / 1991 / Cyclosporine for plaque-type psoriasis. Results of a multidose, double-blind trial / N Engl J Med 324 : 277 ~ 284
Garcia-Bustinduy M / 2004 / Safety of long-term treatment with cyclosporin A in resistant chronic plaque psoriasis: a retrospective case series / J Eur Acad Dermatol Venereo
Greaves MW / 1995 / Treatment of psoriasis / N Engl J Med 332 : 581 ~ 588
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