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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 20 - 24 (5page)
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We present a case of cytokeratin (CK) 20-positive large cell neuroendocrine carcinoma (LCNEC) presenting with multiple skin metastases as the primary manifestation. The patient was a 55-year-old man who presented with a one- month history of subcutaneous skin colored nodules of various sizes on his trunk. Pathologic examination of the skin revealed a nested and solid proliferation of large undifferentiated cells with vesicular nuclei and prominent nucleoli. Tumor cells were found to be immunohistochemically positive for CK 20,chromogranin A, synaptophysin, and CD56. Based on these features, the tumor was diagnosed as a large cell neuroendocrine carcinoma with multiple skin metastases.
Computed tomographic (CT) imaging found metastatic foci in the liver, pleura, bone, and lymph nodes. We were unable to identify the primary site of origin. To the best of our knowledge,this is the first case of a large cell neuroendocrine carcinoma with a primary manifestation of multiple skin metastases. (Ann Dermatol 23(S1) S20∼S24, 2011)
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참고문헌 (19)
참고문헌 신청
Adegbola T / 2005 / Small cell neuroendocrine carcinoma of the breast: a report of three cases and review of the literature / J Clin Pathol 58 : 775 ~ 778
Chu P / 2000 / Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases / Mod Pathol 13 : 962 ~ 972
Dundr P / 2003 / Large cell neuroendocrine carcinoma of the urinary bladder with lymphoepithelioma-like features / Pathol Res Pract 199 : 559 ~ 563
Dundr P / 2008 / Primary pure large-cell neuroendocrine carcinoma of the ovary / Pathol Res Pract 204 : 133 ~ 137
Grabowski P / 2002 / Expression of neuroendocrine markers: a signature of human undifferentiated carcinoma of the colon and rectum / Virchows Arch 441 : 256 ~ 263
Chu P / 2000 / Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases / Mod Pathol 13 : 962 ~ 972
Dundr P / 2003 / Large cell neuroendocrine carcinoma of the urinary bladder with lymphoepithelioma-like features / Pathol Res Pract 199 : 559 ~ 563
Dundr P / 2008 / Primary pure large-cell neuroendocrine carcinoma of the ovary / Pathol Res Pract 204 : 133 ~ 137
Grabowski P / 2002 / Expression of neuroendocrine markers: a signature of human undifferentiated carcinoma of the colon and rectum / Virchows Arch 441 : 256 ~ 263
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